Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 4216693..4217218 Replicon chromosome
Accession NC_016111
Organism Streptomyces cattleya NRRL 8057 = DSM 46488

Toxin (Protein)


Gene name relE Uniprot ID F8K3H9
Locus tag SCAT_RS26780 Protein ID WP_014144656.1
Coordinates 4216693..4216956 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G8WSR4
Locus tag SCAT_RS26785 Protein ID WP_014628308.1
Coordinates 4216949..4217218 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SCAT_RS26760 4211872..4213227 + 1356 WP_014144652.1 hypothetical protein -
SCAT_RS26765 4213229..4213759 + 531 WP_014144653.1 NUDIX domain-containing protein -
SCAT_RS26770 4213890..4214717 + 828 WP_014144654.1 TIGR04255 family protein -
SCAT_RS26775 4215423..4216385 + 963 WP_157894840.1 hypothetical protein -
SCAT_RS26780 4216693..4216956 - 264 WP_014144656.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SCAT_RS26785 4216949..4217218 - 270 WP_014628308.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SCAT_RS26790 4217400..4218818 + 1419 WP_014144658.1 ATP-binding protein -
SCAT_RS26795 4218939..4220651 + 1713 WP_014142185.1 IS1182 family transposase -
SCAT_RS38910 4220776..4221129 + 354 WP_014144659.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 4200367..4241917 41550


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9968.42 Da        Isoelectric Point: 9.5565

>T25678 WP_014144656.1 NC_016111:c4216956-4216693 [Streptomyces cattleya NRRL 8057 = DSM 46488]
VSEYRTVFRPEAQAELRKVPRDMALRILAKLTELESDPLGFNTTALVSQPDRRRLRVGDYRVIYTIDNGELVVWVVHVGH
RSTVYGA

Download         Length: 264 bp

>T25678 NC_016111:c4216956-4216693 [Streptomyces cattleya NRRL 8057 = DSM 46488]
GTGAGTGAGTACCGCACCGTCTTCCGACCCGAGGCTCAGGCCGAACTCCGCAAGGTCCCGCGCGACATGGCTCTCCGCAT
TCTGGCCAAGCTGACCGAGCTGGAGAGCGACCCGCTGGGATTCAACACCACTGCTCTCGTCTCCCAGCCCGACCGGCGCC
GCCTACGGGTCGGCGACTACCGCGTGATCTACACGATCGACAATGGTGAGCTGGTGGTGTGGGTCGTGCATGTCGGGCAT
CGCTCAACCGTCTACGGCGCCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10322.79 Da        Isoelectric Point: 4.7473

>AT25678 WP_014628308.1 NC_016111:c4217218-4216949 [Streptomyces cattleya NRRL 8057 = DSM 46488]
MTQPLPMESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMANPTPGVPIEDI
MRETLARSE

Download         Length: 270 bp

>AT25678 NC_016111:c4217218-4216949 [Streptomyces cattleya NRRL 8057 = DSM 46488]
ATGACACAACCGCTGCCCATGGAGTCCATCCGCGATGTCCGGGCACACCTCGCCGAGGTCGTGGAGCGGGCTGACCGCGA
CGACGTGCCCACGGTGATCACGCGCCGAGGCAAGCAGGTGGCTGCCGTGGTGTCCATCGAAGTGCTCCGGAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGAATCATCGATGAGCGCATGGCCAACCCGACACCCGGCGTCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCAGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8K3H9

Antitoxin

Source ID Structure
AlphaFold DB G8WSR4

References