Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) relBE/PHD-RelE
Location 3177537..3178085 Replicon chromosome
Accession NC_000962
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name relE Uniprot ID O33348
Locus tag Rv2866 Protein ID NP_217382.1
Coordinates 3177822..3178085 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag Rv2865 Protein ID NP_217381.1
Coordinates 3177537..3177818 (+) Length 94 a.a.

Genomic Context

Rv2862ARv2863Rv2865Rv2866Rv2861cRv2862cRv2864cRv2867cRv2868cRv2869cRv2870c
Location: 3174747..3174995 (249 bp)
Type: Others
Protein ID: YP_007411570.1
Location: 3174992..3175372 (381 bp)
Type: Others
Protein ID: NP_217379.1
Location: 3177537..3177818 (282 bp)
Type: Antitoxin
Protein ID: NP_217381.1
Location: 3177822..3178085 (264 bp)
Type: Toxin
Protein ID: NP_217382.1
Location: 3173160..3174017 (858 bp)
Type: Others
Protein ID: YP_177911.1
Location: 3174059..3174643 (585 bp)
Type: Others
Protein ID: NP_217378.1
Location: 3175454..3177265 (1812 bp)
Type: Others
Protein ID: NP_217380.1
Location: 3178458..3179312 (855 bp)
Type: Others
Protein ID: NP_217383.1
Location: 3179368..3180531 (1164 bp)
Type: Others
Protein ID: NP_217384.1
Location: 3180548..3181762 (1215 bp)
Type: Others
Protein ID: NP_217385.1
Location: 3181770..3183011 (1242 bp)
Type: Others
Protein ID: NP_217386.2
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Rv2861c3173160..3174017-858YP_177911.1methionine aminopeptidase-
Rv2862c3174059..3174643-585NP_217378.1hypothetical protein-
Rv2862A3174747..3174995+249YP_007411570.1antitoxin VapB23-
Rv28633174992..3175372+381NP_217379.1ribonuclease VapC23-
Rv2864c3175454..3177265-1812NP_217380.1penicillin-binding lipoprotein-
Rv28653177537..3177818+282NP_217381.1antitoxin RelFAntitoxin
Rv28663177822..3178085+264NP_217382.1toxin RelGToxin
Rv2867c3178458..3179312-855NP_217383.1GCN5-like N-acetyltransferase-
Rv2868c3179368..3180531-1164NP_217384.14-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)-
Rv2869c3180548..3181762-1215NP_217385.1zinc metalloprotease-
Rv2870c3181770..3183011-1242NP_217386.21-deoxy-D-xylulose 5-phosphate reductoisomerase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T124 NP_217382.1 NC_000962:3177822-3178085 [Mycobacterium tuberculosis H37Rv]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T124 NC_000962:3177822-3178085 [Mycobacterium tuberculosis H37Rv]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGCATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT124 NP_217381.1 NC_000962:3177537-3177818 [Mycobacterium tuberculosis H37Rv]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT124 NC_000962:3177537-3177818 [Mycobacterium tuberculosis H37Rv]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T93Mycobacterium tuberculosis H37Rv

54.118

97.701

0.529

T6285Streptomyces cattleya NRRL 8057 = DSM 46488

31.461

100

0.322

T10158Streptococcus suis SC84

29.885

100

0.302
Showing 1 to 3 of 3 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT93Mycobacterium tuberculosis H37Rv

44.186

96.629

0.427
Showing 1 to 1 of 1 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
PDB3G5O

Antitoxin

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Source
ID
Structure
PDB3G5O
AlphaFold DBO33347

References

(1) Shaleen B Korch et al. (2009) Three Mycobacterium tuberculosis Rel toxin-antitoxin modules inhibit mycobacterial growth and are expressed in infected human macrophages. Journal of Bacteriology 191(5):1618-30. [PubMed:19114484] experimental


experimental experimental literature