10158

Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 1438776..1439259 Replicon chromosome
Accession NC_012924
Organism Streptococcus suis SC84

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag SSUSC84_RS07050 Protein ID WP_012027435.1
Coordinates 1438776..1439036 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag SSUSC84_RS07055 Protein ID WP_012775256.1
Coordinates 1439038..1439259 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUSC84_RS07025 (SSUSC84_1343) 1434161..1435390 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
SSUSC84_RS07030 (SSUSC84_1344) 1435380..1436546 - 1167 WP_012775254.1 AI-2E family transporter -
SSUSC84_RS07035 (SSUSC84_1345) 1436682..1437686 + 1005 WP_012028380.1 lactonase family protein -
SSUSC84_RS07040 (SSUSC84_1346) 1437750..1437935 + 186 WP_002935693.1 hypothetical protein -
SSUSC84_RS07045 (SSUSC84_1347) 1437968..1438609 - 642 WP_012775255.1 HAD family hydrolase -
SSUSC84_RS07050 (SSUSC84_1348) 1438776..1439036 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUSC84_RS07055 (SSUSC84_1349) 1439038..1439259 - 222 WP_012775256.1 hypothetical protein Antitoxin
SSUSC84_RS07060 (SSUSC84_1350) 1439569..1440876 - 1308 WP_002935704.1 phosphopyruvate hydratase -
SSUSC84_RS07065 (SSUSC84_1351) 1441026..1441478 + 453 WP_012028381.1 DUF1694 domain-containing protein -
SSUSC84_RS10580 1441485..1441714 - 230 Protein_1344 hypothetical protein -
SSUSC84_RS07070 (SSUSC84_1352) 1441705..1442832 - 1128 WP_012028382.1 glycerate kinase -
SSUSC84_RS07075 (SSUSC84_1353) 1442940..1443590 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1444027..1445229 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T10158 WP_012027435.1 NC_012924:c1439036-1438776 [Streptococcus suis SC84]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T10158 NC_012924:c1439036-1438776 [Streptococcus suis SC84]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT10158 WP_012775256.1 NC_012924:c1439259-1439038 [Streptococcus suis SC84]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT10158 NC_012924:c1439259-1439038 [Streptococcus suis SC84]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
T10157 Streptococcus suis SC84

51.765

98.837

0.512
T727 Streptococcus pneumoniae R6

45.349

100

0.464
T326 Streptococcus pneumoniae TIGR4

45.349

100

0.464
T10191 Synechococcus sp. CB0101

35.714

100

0.357
T1729 Acidithiobacillus caldus

33.721

100

0.337
T124 Mycobacterium tuberculosis H37Rv

29.885

100

0.302
T10123 Paracoccus phage vB_PkoS_Pkon1

29.07

100

0.301

Multiple sequence alignment    


Protein Organism Identities (%) Coverage (%) Ha-value
AT10157 Streptococcus suis SC84

46.479

97.26

0.452
AT326 Streptococcus pneumoniae TIGR4

33.766

100

0.356
AT727 Streptococcus pneumoniae R6

33.766

100

0.356

Multiple sequence alignment    




Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References

(1) Jiali Xu et al. (2018) Identification of Three Type II Toxin-Antitoxin Systems in Streptococcus suis Serotype 2. Toxins 10(11):467. [PubMed:30428568] experimental


experimental experimental literature