Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 1438776..1439259 Replicon chromosome
Accession NC_012924
Organism Streptococcus suis SC84

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag SSUSC84_RS07050 Protein ID WP_012027435.1
Coordinates 1438776..1439036 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag SSUSC84_RS07055 Protein ID WP_012775256.1
Coordinates 1439038..1439259 (-) Length 74 a.a.

Genomic Context

SSUSC84_RS07035SSUSC84_RS07040SSUSC84_RS07065SSUSC84_RS07075SSUSC84_RS07025SSUSC84_RS07030SSUSC84_RS07045SSUSC84_RS07050SSUSC84_RS07055SSUSC84_RS07060SSUSC84_RS10580SSUSC84_RS07070
Location: 1436682..1437686 (1005 bp)
Type: Others
Protein ID: WP_012028380.1
Location: 1437750..1437935 (186 bp)
Type: Others
Protein ID: WP_002935693.1
Location: 1441026..1441478 (453 bp)
Type: Others
Protein ID: WP_012028381.1
Location: 1442940..1443590 (651 bp)
Type: Others
Protein ID: WP_012027441.1
Location: 1434161..1435390 (1230 bp)
Type: Others
Protein ID: WP_012775253.1
Location: 1435380..1436546 (1167 bp)
Type: Others
Protein ID: WP_012775254.1
Location: 1437968..1438609 (642 bp)
Type: Others
Protein ID: WP_012775255.1
Location: 1438776..1439036 (261 bp)
Type: Toxin
Protein ID: WP_012027435.1
Location: 1439038..1439259 (222 bp)
Type: Antitoxin
Protein ID: WP_012775256.1
Location: 1439569..1440876 (1308 bp)
Type: Others
Protein ID: WP_002935704.1
Location: 1441485..1441714 (230 bp)
Type: Others
Protein ID: Protein_1344
Location: 1441705..1442832 (1128 bp)
Type: Others
Protein ID: WP_012028382.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SSUSC84_RS07025 (SSUSC84_1343)1434161..1435390-1230WP_012775253.1tetratricopeptide repeat protein-
SSUSC84_RS07030 (SSUSC84_1344)1435380..1436546-1167WP_012775254.1AI-2E family transporter-
SSUSC84_RS07035 (SSUSC84_1345)1436682..1437686+1005WP_012028380.1lactonase family protein-
SSUSC84_RS07040 (SSUSC84_1346)1437750..1437935+186WP_002935693.1hypothetical protein-
SSUSC84_RS07045 (SSUSC84_1347)1437968..1438609-642WP_012775255.1HAD family hydrolase-
SSUSC84_RS07050 (SSUSC84_1348)1438776..1439036-261WP_012027435.1type II toxin-antitoxin system RelE/ParE family toxinToxin
SSUSC84_RS07055 (SSUSC84_1349)1439038..1439259-222WP_012775256.1hypothetical proteinAntitoxin
SSUSC84_RS07060 (SSUSC84_1350)1439569..1440876-1308WP_002935704.1phosphopyruvate hydratase-
SSUSC84_RS07065 (SSUSC84_1351)1441026..1441478+453WP_012028381.1DUF1694 domain-containing protein-
SSUSC84_RS105801441485..1441714-230Protein_1344hypothetical protein-
SSUSC84_RS07070 (SSUSC84_1352)1441705..1442832-1128WP_012028382.1glycerate kinase-
SSUSC84_RS07075 (SSUSC84_1353)1442940..1443590+651WP_012027441.1HAD family hydrolase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--1444027..14452291202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T10158 WP_012027435.1 NC_012924:c1439036-1438776 [Streptococcus suis SC84]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T10158 NC_012924:c1439036-1438776 [Streptococcus suis SC84]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT10158 WP_012775256.1 NC_012924:c1439259-1439038 [Streptococcus suis SC84]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT10158 NC_012924:c1439259-1439038 [Streptococcus suis SC84]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T10157Streptococcus suis SC84

51.765

98.837

0.512

T727Streptococcus pneumoniae R6

45.349

100

0.464

T326Streptococcus pneumoniae TIGR4

45.349

100

0.464

T10191Synechococcus sp. CB0101

35.714

100

0.357

T1729Acidithiobacillus caldus

33.721

100

0.337

T124Mycobacterium tuberculosis H37Rv

29.885

100

0.302

T10123Paracoccus phage vB_PkoS_Pkon1

29.07

100

0.301
Showing 1 to 7 of 7 rows

Multiple sequence alignment    


Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT10157Streptococcus suis SC84

46.479

97.26

0.452

AT326Streptococcus pneumoniae TIGR4

33.766

100

0.356

AT727Streptococcus pneumoniae R6

33.766

100

0.356
Showing 1 to 3 of 3 rows

Multiple sequence alignment    




Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A2K1T1M7

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0Z8BIX7

References

(1) Jiali Xu et al. (2018) Identification of Three Type II Toxin-Antitoxin Systems in Streptococcus suis Serotype 2. Toxins 10(11):467. [PubMed:30428568] experimental


experimental experimental literature