Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1405790..1406273 Replicon chromosome
Accession NZ_CP082200
Organism Streptococcus suis strain Transconjugant cDY107

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag K6971_RS06890 Protein ID WP_012027435.1
Coordinates 1405790..1406050 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag K6971_RS06895 Protein ID WP_012775256.1
Coordinates 1406052..1406273 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6971_RS06865 (K6971_06865) 1401175..1402404 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
K6971_RS06870 (K6971_06870) 1402394..1403560 - 1167 WP_012775254.1 AI-2E family transporter -
K6971_RS06875 (K6971_06875) 1403696..1404700 + 1005 WP_012028380.1 lactonase family protein -
K6971_RS06880 (K6971_06880) 1404764..1404949 + 186 WP_002935693.1 hypothetical protein -
K6971_RS06885 (K6971_06885) 1404982..1405623 - 642 WP_012775255.1 HAD family hydrolase -
K6971_RS06890 (K6971_06890) 1405790..1406050 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6971_RS06895 (K6971_06895) 1406052..1406273 - 222 WP_012775256.1 DUF6290 family protein Antitoxin
K6971_RS06900 (K6971_06900) 1406583..1407890 - 1308 WP_002935704.1 phosphopyruvate hydratase -
K6971_RS06905 (K6971_06905) 1408040..1408492 + 453 WP_012028381.1 DUF1694 domain-containing protein -
K6971_RS06910 (K6971_06910) 1408558..1408728 - 171 WP_014636067.1 hypothetical protein -
K6971_RS06915 (K6971_06915) 1408719..1409846 - 1128 WP_012028382.1 glycerate kinase -
K6971_RS06920 (K6971_06920) 1409954..1410604 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1411041..1412243 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T214290 WP_012027435.1 NZ_CP082200:c1406050-1405790 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T214290 NZ_CP110018:c3331571-3331257 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT214290 WP_012775256.1 NZ_CP082200:c1406273-1406052 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT214290 NZ_CP110018:c3331260-3330844 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References