233290

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1413589..1414072 Replicon chromosome
Accession NZ_CP091422
Organism Streptococcus suis strain LSM157

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag L3X06_RS06915 Protein ID WP_012027435.1
Coordinates 1413589..1413849 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag L3X06_RS06920 Protein ID WP_012775256.1
Coordinates 1413851..1414072 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3X06_RS06890 (L3X06_06890) 1408974..1410203 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
L3X06_RS06895 (L3X06_06895) 1410193..1411359 - 1167 WP_012775254.1 AI-2E family transporter -
L3X06_RS06900 (L3X06_06900) 1411495..1412499 + 1005 WP_012028380.1 lactonase family protein -
L3X06_RS06905 (L3X06_06905) 1412563..1412748 + 186 WP_002935693.1 hypothetical protein -
L3X06_RS06910 (L3X06_06910) 1412781..1413422 - 642 WP_012775255.1 HAD family hydrolase -
L3X06_RS06915 (L3X06_06915) 1413589..1413849 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L3X06_RS06920 (L3X06_06920) 1413851..1414072 - 222 WP_012775256.1 DUF6290 family protein Antitoxin
L3X06_RS06925 (L3X06_06925) 1414382..1415689 - 1308 WP_002935704.1 phosphopyruvate hydratase -
L3X06_RS06930 (L3X06_06930) 1415839..1416291 + 453 WP_012028381.1 DUF1694 domain-containing protein -
L3X06_RS06935 (L3X06_06935) 1416357..1416527 - 171 WP_014636067.1 hypothetical protein -
L3X06_RS06940 (L3X06_06940) 1416518..1417645 - 1128 WP_012028382.1 glycerate kinase -
L3X06_RS06945 (L3X06_06945) 1417753..1418403 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1418840..1420042 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T233290 WP_012027435.1 NZ_CP091422:c1413849-1413589 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T233290 NZ_HG326223:3477390-3477635 [Serratia marcescens subsp. marcescens Db11]
ATTTCGCTCAATCGGGGTAAACGGGGTGGTGCTCGATCCATCGTGGCGTTTAAACGCGGTCGTCATCAGTATTTTATTGA
TGGATGGCTGAAAAACACCGTAAAACAGAACGGTGCAAAAGAAATCAACGATGATGAATTGGCAACCTATCGCGAGCTCG
CCAGAGATTTTCTTGCCATGCCGCCGGAAATTATCAAACGAGCCATCGATAGCGGCTACTTGCGAGAGGTGAAATGCGAT
GACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT233290 WP_012775256.1 NZ_CP091422:c1414072-1413851 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT233290 NZ_HG326223:3477628-3477972 [Serratia marcescens subsp. marcescens Db11]
ATGACTGATAATCGCCTGCTCAGACTGCAAAAAATGGCACAGCGTTTTAATGAGATCGGTGCGGTGTCAGACGATACCGT
ACGCAACATCGCCACACGAGTACAGGCGCAGGAACAACATGCCCAGCGTGAGCAGCATGATCAAATGGACGGCGCACGCA
TCAAAATGCTGCGCAGACGGCTCGGCCTGAGCCAGGCCGATTTAGCGGCCGTGGTCAACATGTCGACCACCAGCGTACAA
AAATGGGAACGTAACGCGGTAAAACCCCAGGGAGCCGCGCTCAGAATGCTGGAAATTATCGAACAGAAAGGGGTCGCTAG
CCTGATCATCTCACCACGAAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References