262475

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1442939..1443422 Replicon chromosome
Accession NZ_CP109942
Organism Streptococcus suis strain ID35541

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag OHM48_RS07085 Protein ID WP_012027435.1
Coordinates 1442939..1443199 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag OHM48_RS07090 Protein ID WP_012775256.1
Coordinates 1443201..1443422 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM48_RS07060 (OHM48_07060) 1438324..1439553 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
OHM48_RS07065 (OHM48_07065) 1439543..1440709 - 1167 WP_012775254.1 AI-2E family transporter -
OHM48_RS07070 (OHM48_07070) 1440845..1441849 + 1005 WP_012028380.1 lactonase family protein -
OHM48_RS07075 (OHM48_07075) 1441913..1442098 + 186 WP_002935693.1 hypothetical protein -
OHM48_RS07080 (OHM48_07080) 1442131..1442772 - 642 WP_012775255.1 HAD family hydrolase -
OHM48_RS07085 (OHM48_07085) 1442939..1443199 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OHM48_RS07090 (OHM48_07090) 1443201..1443422 - 222 WP_012775256.1 DUF6290 family protein Antitoxin
OHM48_RS07095 (OHM48_07095) 1443732..1445039 - 1308 WP_002935704.1 phosphopyruvate hydratase -
OHM48_RS07100 (OHM48_07100) 1445189..1445641 + 453 WP_012028381.1 DUF1694 domain-containing protein -
OHM48_RS07105 (OHM48_07105) 1445648..1445878 - 231 WP_014917285.1 hypothetical protein -
OHM48_RS07110 (OHM48_07110) 1445869..1446996 - 1128 WP_012028382.1 glycerate kinase -
OHM48_RS07115 (OHM48_07115) 1447104..1447754 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1448191..1449393 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T262475 WP_012027435.1 NZ_CP109942:c1443199-1442939 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT262475 WP_012775256.1 NZ_CP109942:c1443422-1443201 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References