75585

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1438847..1439330 Replicon chromosome
Accession NZ_CP020863
Organism Streptococcus suis strain SC19

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag B9H01_RS07235 Protein ID WP_012027435.1
Coordinates 1438847..1439107 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag B9H01_RS07240 Protein ID WP_012775256.1
Coordinates 1439109..1439330 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9H01_RS07210 1434232..1435461 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
B9H01_RS07215 1435451..1436617 - 1167 WP_012775254.1 AI-2E family transporter -
B9H01_RS07220 1436753..1437757 + 1005 WP_012028380.1 lactonase family protein -
B9H01_RS07225 1437821..1438006 + 186 WP_002935693.1 hypothetical protein -
B9H01_RS07230 1438039..1438680 - 642 WP_012775255.1 HAD family hydrolase -
B9H01_RS07235 1438847..1439107 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B9H01_RS07240 1439109..1439330 - 222 WP_012775256.1 hypothetical protein Antitoxin
B9H01_RS07245 1439640..1440947 - 1308 WP_002935704.1 phosphopyruvate hydratase -
B9H01_RS07250 1441097..1441549 + 453 WP_012028381.1 DUF1694 domain-containing protein -
B9H01_RS07255 1441556..1441785 - 230 Protein_1344 hypothetical protein -
B9H01_RS07260 1441776..1442903 - 1128 WP_012028382.1 glycerate kinase -
B9H01_RS07265 1443011..1443661 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1444098..1445300 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T75585 WP_012027435.1 NZ_CP020863:c1439107-1438847 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T75585 NZ_CP020863:c1439107-1438847 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT75585 WP_012775256.1 NZ_CP020863:c1439330-1439109 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT75585 NZ_CP020863:c1439330-1439109 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References