70796

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1414155..1414638 Replicon chromosome
Accession NZ_CP018908
Organism Streptococcus suis strain SS2-1

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag BVD85_RS07065 Protein ID WP_012027435.1
Coordinates 1414155..1414415 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag BVD85_RS07070 Protein ID WP_012775256.1
Coordinates 1414417..1414638 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVD85_RS07040 1409540..1410769 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
BVD85_RS07045 1410759..1411925 - 1167 WP_012775254.1 AI-2E family transporter -
BVD85_RS07050 1412061..1413065 + 1005 WP_012028380.1 lactonase family protein -
BVD85_RS07055 1413129..1413314 + 186 WP_002935693.1 hypothetical protein -
BVD85_RS07060 1413347..1413988 - 642 WP_012775255.1 HAD family hydrolase -
BVD85_RS07065 1414155..1414415 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVD85_RS07070 1414417..1414638 - 222 WP_012775256.1 hypothetical protein Antitoxin
BVD85_RS07075 1414948..1416255 - 1308 WP_002935704.1 phosphopyruvate hydratase -
BVD85_RS07080 1416405..1416857 + 453 WP_012028381.1 DUF1694 domain-containing protein -
BVD85_RS07085 1416864..1417093 - 230 Protein_1329 hypothetical protein -
BVD85_RS07090 1417084..1418211 - 1128 WP_012028382.1 glycerate kinase -
BVD85_RS07095 1418319..1418969 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1419406..1420608 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T70796 WP_012027435.1 NZ_CP018908:c1414415-1414155 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T70796 NZ_CP018908:c1414415-1414155 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT70796 WP_012775256.1 NZ_CP018908:c1414638-1414417 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT70796 NZ_CP018908:c1414638-1414417 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References