254110

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1350395..1350878 Replicon chromosome
Accession NZ_CP102746
Organism Streptococcus suis strain Transconjugant cAKJ47-2

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag NWE23_RS06580 Protein ID WP_012027435.1
Coordinates 1350395..1350655 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag NWE23_RS06585 Protein ID WP_012775256.1
Coordinates 1350657..1350878 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWE23_RS06555 (NWE23_06565) 1345780..1347009 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
NWE23_RS06560 (NWE23_06570) 1346999..1348165 - 1167 WP_012775254.1 AI-2E family transporter -
NWE23_RS06565 (NWE23_06575) 1348301..1349305 + 1005 WP_012028380.1 lactonase family protein -
NWE23_RS06570 (NWE23_06580) 1349369..1349554 + 186 WP_002935693.1 hypothetical protein -
NWE23_RS06575 (NWE23_06585) 1349587..1350228 - 642 WP_012775255.1 HAD family hydrolase -
NWE23_RS06580 (NWE23_06590) 1350395..1350655 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWE23_RS06585 (NWE23_06595) 1350657..1350878 - 222 WP_012775256.1 DUF6290 family protein Antitoxin
NWE23_RS06590 (NWE23_06600) 1351188..1352495 - 1308 WP_002935704.1 phosphopyruvate hydratase -
NWE23_RS06595 (NWE23_06605) 1352645..1353097 + 453 WP_012028381.1 DUF1694 domain-containing protein -
NWE23_RS06600 (NWE23_06610) 1353163..1353333 - 171 WP_014636067.1 hypothetical protein -
NWE23_RS06605 (NWE23_06615) 1353324..1354451 - 1128 WP_012028382.1 glycerate kinase -
NWE23_RS06610 (NWE23_06620) 1354559..1355209 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1355646..1356848 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T254110 WP_012027435.1 NZ_CP102746:c1350655-1350395 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT254110 WP_012775256.1 NZ_CP102746:c1350878-1350657 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References