Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/- |
| Location | 596661..597147 | Replicon | chromosome |
| Accession | NC_012924 | ||
| Organism | Streptococcus suis SC84 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D5AGV2 |
| Locus tag | SSUSC84_RS02995 | Protein ID | WP_011922754.1 |
| Coordinates | 596878..597147 (+) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D5AGV1 |
| Locus tag | SSUSC84_RS02990 | Protein ID | WP_002938604.1 |
| Coordinates | 596661..596888 (+) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SSUSC84_RS02960 (SSUSC84_0541) | 591704..592153 | - | 450 | WP_009909619.1 | MarR family transcriptional regulator | - |
| SSUSC84_RS10415 | 592447..593294 | + | 848 | WP_087892711.1 | IS630 family transposase | - |
| SSUSC84_RS02975 (SSUSC84_0544) | 593353..593850 | + | 498 | WP_011922751.1 | DUF5590 domain-containing protein | - |
| SSUSC84_RS02980 (SSUSC84_0545) | 593847..595028 | + | 1182 | WP_011922154.1 | pyridoxal phosphate-dependent aminotransferase | - |
| SSUSC84_RS02985 (SSUSC84_0546) | 595043..596389 | + | 1347 | WP_011922752.1 | asparagine--tRNA ligase | - |
| SSUSC84_RS02990 (SSUSC84_0547) | 596661..596888 | + | 228 | WP_002938604.1 | hypothetical protein | Antitoxin |
| SSUSC84_RS02995 (SSUSC84_0548) | 596878..597147 | + | 270 | WP_011922754.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| SSUSC84_RS03000 (SSUSC84_0549) | 597553..598872 | + | 1320 | WP_012775027.1 | MATE family efflux transporter | - |
| SSUSC84_RS03005 (SSUSC84_0550) | 598923..599300 | + | 378 | WP_002937263.1 | RidA family protein | - |
| SSUSC84_RS03010 (SSUSC84_0551) | 599322..600209 | + | 888 | WP_011922160.1 | RNase adapter RapZ | - |
| SSUSC84_RS03015 (SSUSC84_0552) | 600206..601180 | + | 975 | WP_002937257.1 | YvcK family protein | - |
| SSUSC84_RS03020 (SSUSC84_0553) | 601177..602094 | + | 918 | WP_002937252.1 | DNA-binding protein WhiA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10437.49 Da Isoelectric Point: 10.3916
>T10157 WP_011922754.1 NC_012924:596878-597147 [Streptococcus suis SC84]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK
Download Length: 270 bp
>T10157 NC_012924:596878-597147 [Streptococcus suis SC84]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8450.51 Da Isoelectric Point: 4.1589
>AT10157 WP_002938604.1 NC_012924:596661-596888 [Streptococcus suis SC84]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL
Download Length: 228 bp
>AT10157 NC_012924:596661-596888 [Streptococcus suis SC84]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T727 | Streptococcus pneumoniae R6 |
50.588 |
100 |
0.512 |
| T326 | Streptococcus pneumoniae TIGR4 |
50.588 |
100 |
0.512 |
| T10158 | Streptococcus suis SC84 |
51.765 |
98.837 |
0.512 |
| T1729 | Acidithiobacillus caldus |
38.889 |
100 |
0.393 |
| T1041 | Escherichia coli str. K-12 substr. MG1655 |
33.684 |
100 |
0.36 |
| T173 | Vibrio cholerae O1 biovar El Tor str. N16961 |
32.632 |
100 |
0.348 |
| T175 | Vibrio cholerae O1 biovar El Tor str. N16961 |
32.258 |
100 |
0.337 |
| T6285 | Streptomyces cattleya NRRL 8057 = DSM 46488 |
32.184 |
100 |
0.322 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT10158 | Streptococcus suis SC84 |
46.479 |
97.26 |
0.452 |
Multiple sequence alignment
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A126UKS2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A140EXF0 |
References
(1) Jiali Xu et al. (2018) Identification of Three Type II Toxin-Antitoxin Systems in Streptococcus suis Serotype 2. Toxins 10(11):467. [PubMed:30428568]