Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH-RelE |
| Location | 1156713..1157271 | Replicon | chromosome |
| Accession | NC_003028 | ||
| Organism | Streptococcus pneumoniae TIGR4 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | B1IC19 |
| Locus tag | SP_RS05995 | Protein ID | WP_001809704.1 |
| Coordinates | 1156713..1156967 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | B1IC20 |
| Locus tag | SP_RS06000 | Protein ID | WP_000208080.1 |
| Coordinates | 1156969..1157211 (-) | Length | 81 a.a. |
Genomic Context
Location: 1154767..1156638 (1872 bp)
Type: Others
Protein ID: WP_000150986.1
Type: Others
Protein ID: WP_000150986.1
Location: 1156713..1156967 (255 bp)
Type: Toxin
Protein ID: WP_001809704.1
Type: Toxin
Protein ID: WP_001809704.1
Location: 1156969..1157211 (243 bp)
Type: Antitoxin
Protein ID: WP_000208080.1
Type: Antitoxin
Protein ID: WP_000208080.1
Location: 1157302..1158111 (810 bp)
Type: Others
Protein ID: WP_001289493.1
Type: Others
Protein ID: WP_001289493.1
Location: 1158113..1159462 (1350 bp)
Type: Others
Protein ID: WP_000886219.1
Type: Others
Protein ID: WP_000886219.1
Location: 1159455..1160159 (705 bp)
Type: Others
Protein ID: WP_000722076.1
Type: Others
Protein ID: WP_000722076.1
Location: 1160215..1161390 (1176 bp)
Type: Others
Protein ID: WP_000886146.1
Type: Others
Protein ID: WP_000886146.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SP_RS05990 (SP_1222) | 1154767..1156638 | - | 1872 | WP_000150986.1 | Eco57I restriction-modification methylase domain-containing protein | - |
| SP_RS05995 (SP_1223) | 1156713..1156967 | - | 255 | WP_001809704.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| SP_RS06000 (SP_1224) | 1156969..1157211 | - | 243 | WP_000208080.1 | hypothetical protein | Antitoxin |
| SP_RS06005 (SP_1225) | 1157302..1158111 | - | 810 | WP_001289493.1 | MBL fold metallo-hydrolase | - |
| SP_RS06010 (SP_1226) | 1158113..1159462 | - | 1350 | WP_000886219.1 | cell wall metabolism sensor histidine kinase VicK | - |
| SP_RS06015 (SP_1227) | 1159455..1160159 | - | 705 | WP_000722076.1 | response regulator transcription factor | - |
| SP_RS06020 (SP_1228) | 1160215..1161390 | - | 1176 | WP_000886146.1 | A/G-specific adenine glycosylase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10098.79 Da Isoelectric Point: 10.7632
>T326 WP_001809704.1 NC_003028:c1156967-1156713 [Streptococcus pneumoniae TIGR4]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY
Download Length: 255 bp
>T326 NC_003028:c1156967-1156713 [Streptococcus pneumoniae TIGR4]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9205.46 Da Isoelectric Point: 4.0527
>AT326 WP_000208080.1 NC_003028:c1157211-1156969 [Streptococcus pneumoniae TIGR4]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE
Download Length: 243 bp
>AT326 NC_003028:c1157211-1156969 [Streptococcus pneumoniae TIGR4]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA
Similar Proteins
Only experimentally validated proteins are listed.
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T727 | Streptococcus pneumoniae R6 | 100 | 100 | 1 |
| T10157 | Streptococcus suis SC84 | 50.588 | 100 | 0.512 |
| T10158 | Streptococcus suis SC84 | 45.349 | 100 | 0.464 |
| T1729 | Acidithiobacillus caldus | 40.789 | 90.476 | 0.369 |
| T10123 | Paracoccus phage vB_PkoS_Pkon1 | 34.483 | 100 | 0.361 |
Showing 1 to 5 of 5 rows
Multiple sequence alignment
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT727 | Streptococcus pneumoniae R6 | 100 | 100 | 1 |
| AT10158 | Streptococcus suis SC84 | 33.766 | 100 | 0.356 |
Showing 1 to 2 of 2 rows
Multiple sequence alignment
Structures
Toxin
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Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A853PEW4 |
Antitoxin
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Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A064C2J7 |
References
(1) Concha Nieto et al. (2010) The relBE2Spn toxin-antitoxin system of Streptococcus pneumoniae: role in antibiotic tolerance and functional conservation in clinical isolates. PloS One 5(6):e11289. [PubMed:20585658]