Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 713041..713524 Replicon chromosome
Accession NZ_CP095463
Organism Streptococcus suis strain TJS56

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag MU520_RS03545 Protein ID WP_012027435.1
Coordinates 713264..713524 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag MU520_RS03540 Protein ID WP_012775256.1
Coordinates 713041..713262 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU520_RS03515 708710..709360 - 651 WP_012027441.1 HAD family hydrolase -
MU520_RS03520 709468..710595 + 1128 WP_012028382.1 glycerate kinase -
MU520_RS03525 710586..710756 + 171 WP_014636067.1 hypothetical protein -
MU520_RS03530 710822..711274 - 453 WP_012028381.1 DUF1694 domain-containing protein -
MU520_RS03535 711424..712731 + 1308 WP_002935704.1 phosphopyruvate hydratase -
MU520_RS03540 713041..713262 + 222 WP_012775256.1 DUF6290 family protein Antitoxin
MU520_RS03545 713264..713524 + 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU520_RS03550 713691..714332 + 642 WP_012775255.1 HAD family hydrolase -
MU520_RS03555 714365..714550 - 186 WP_002935693.1 hypothetical protein -
MU520_RS03560 714614..715618 - 1005 WP_012028380.1 lactonase family protein -
MU520_RS03565 715754..716920 + 1167 WP_012775254.1 AI-2E family transporter -
MU520_RS03570 716910..718139 + 1230 WP_012775253.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 643247..714550 71303
flank IS/Tn - - 707071..708273 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T242046 WP_012027435.1 NZ_CP095463:713264-713524 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T242046 NZ_OV040719:c1673963-1673715 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCCCACCCTGAAAATTATATTAAAGGCGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT242046 WP_012775256.1 NZ_CP095463:713041-713262 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT242046 NZ_OV040719:c1673718-1673374 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTATTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References