86626

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1480477..1480960 Replicon chromosome
Accession NZ_CP024050
Organism Streptococcus suis strain CS100322

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag CR541_RS07505 Protein ID WP_012027435.1
Coordinates 1480477..1480737 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag CR541_RS07510 Protein ID WP_012775256.1
Coordinates 1480739..1480960 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR541_RS07480 1475862..1477091 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
CR541_RS07485 1477081..1478247 - 1167 WP_012775254.1 AI-2E family transporter -
CR541_RS07490 1478383..1479387 + 1005 WP_012028380.1 lactonase family protein -
CR541_RS07495 1479451..1479636 + 186 WP_002935693.1 hypothetical protein -
CR541_RS07500 1479669..1480310 - 642 WP_012775255.1 HAD family hydrolase -
CR541_RS07505 1480477..1480737 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CR541_RS07510 1480739..1480960 - 222 WP_012775256.1 hypothetical protein Antitoxin
CR541_RS07515 1481270..1482577 - 1308 WP_002935704.1 phosphopyruvate hydratase -
CR541_RS07520 1482727..1483179 + 453 WP_012028381.1 DUF1694 domain-containing protein -
CR541_RS07525 1483186..1483415 - 230 Protein_1380 hypothetical protein -
CR541_RS07530 1483406..1484533 - 1128 WP_012028382.1 glycerate kinase -
CR541_RS07535 1484641..1485291 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1485728..1486930 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T86626 WP_012027435.1 NZ_CP024050:c1480737-1480477 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T86626 NZ_CP024050:c1480737-1480477 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT86626 WP_012775256.1 NZ_CP024050:c1480960-1480739 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT86626 NZ_CP024050:c1480960-1480739 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References