24000

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1350369..1350852 Replicon chromosome
Accession NC_012925
Organism Streptococcus suis P1/7

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag SSU_RS06660 Protein ID WP_012027435.1
Coordinates 1350369..1350629 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag SSU_RS06665 Protein ID WP_012775256.1
Coordinates 1350631..1350852 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSU_RS06635 1345754..1346983 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
SSU_RS06640 1346973..1348139 - 1167 WP_012775254.1 AI-2E family transporter -
SSU_RS06645 1348275..1349279 + 1005 WP_012028380.1 lactonase family protein -
SSU_RS06650 1349343..1349528 + 186 WP_002935693.1 hypothetical protein -
SSU_RS06655 1349561..1350202 - 642 WP_012775255.1 HAD family hydrolase -
SSU_RS06660 1350369..1350629 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSU_RS06665 1350631..1350852 - 222 WP_012775256.1 hypothetical protein Antitoxin
SSU_RS06670 1351162..1352469 - 1308 WP_002935704.1 phosphopyruvate hydratase -
SSU_RS06675 1352619..1353071 + 453 WP_012028381.1 DUF1694 domain-containing protein -
SSU_RS10185 1353078..1353307 - 230 Protein_1255 hypothetical protein -
SSU_RS06680 1353298..1354425 - 1128 WP_012028382.1 glycerate kinase -
SSU_RS06685 1354533..1355183 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1355620..1356822 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T24000 WP_012027435.1 NC_012925:c1350629-1350369 [Streptococcus suis P1/7]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T24000 NC_012925:c1350629-1350369 [Streptococcus suis P1/7]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT24000 WP_012775256.1 NC_012925:c1350852-1350631 [Streptococcus suis P1/7]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT24000 NC_012925:c1350852-1350631 [Streptococcus suis P1/7]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References