215679

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1480268..1480751 Replicon chromosome
Accession NZ_CP082948
Organism Streptococcus suis strain SZ1908

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag K8227_RS07225 Protein ID WP_012027435.1
Coordinates 1480268..1480528 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag K8227_RS07230 Protein ID WP_012775256.1
Coordinates 1480530..1480751 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8227_RS07200 (K8227_07185) 1475653..1476882 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
K8227_RS07205 (K8227_07190) 1476872..1478038 - 1167 WP_012775254.1 AI-2E family transporter -
K8227_RS07210 (K8227_07195) 1478174..1479178 + 1005 WP_012028380.1 lactonase family protein -
K8227_RS07215 (K8227_07200) 1479242..1479427 + 186 WP_002935693.1 hypothetical protein -
K8227_RS07220 (K8227_07205) 1479460..1480101 - 642 WP_012775255.1 HAD family hydrolase -
K8227_RS07225 (K8227_07210) 1480268..1480528 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8227_RS07230 (K8227_07215) 1480530..1480751 - 222 WP_012775256.1 DUF6290 family protein Antitoxin
K8227_RS07235 (K8227_07220) 1481061..1482368 - 1308 WP_002935704.1 phosphopyruvate hydratase -
K8227_RS07240 (K8227_07225) 1482518..1482970 + 453 WP_012028381.1 DUF1694 domain-containing protein -
K8227_RS07245 (K8227_07230) 1483036..1483206 - 171 WP_014636067.1 hypothetical protein -
K8227_RS07250 (K8227_07235) 1483197..1484324 - 1128 WP_012028382.1 glycerate kinase -
K8227_RS07255 (K8227_07240) 1484432..1485082 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1485519..1486721 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T215679 WP_012027435.1 NZ_CP082948:c1480528-1480268 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T215679 NZ_CP110887:4042767-4043081 [Dickeya solani]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGCTGTTTACCCGCTGTTGCTCGATGTCACAAGCGATATTATTGG
GCAGTTGAATCGCCGGATAGTGATCCCGTTGCTCCCTGTTGAAAAGTATCCGGCAGGCCGCCGACCAGATCGTCTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAGTACGCCGTAATGACGCACGAGCTGGCAAGTATCCCTGTGCAGGCACTGGGG
GCGGTGTTTTGTGATGCGTCTCAGTATCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATCGACGGCATTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT215679 WP_012775256.1 NZ_CP082948:c1480751-1480530 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT215679 NZ_CP110887:4042528-4042764 [Dickeya solani]
ATGACCGCGAAACAACGCAACACGCAAAGCGTGACCATGACGGTGGAGCGTGCCTTACTGGTCCGGGCGCGTGAAGCGGG
CATTAACCTGAGTGCCATCCTGACAACCGCCCTGGATGCAGAGCTTCGCCACCATGAAGCAAAAAAATGGCAGGAAGAGA
ACAGGGAAGCCATCGACGCATTAAACCGTTTTCATGATGAAAATGGCTGTTTCAGTGATGAATACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References