106874

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1418662..1419145 Replicon chromosome
Accession NZ_CP030022
Organism Streptococcus suis strain ISU2714

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag DK876_RS06910 Protein ID WP_012027435.1
Coordinates 1418662..1418922 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag DK876_RS06915 Protein ID WP_012775256.1
Coordinates 1418924..1419145 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK876_RS06885 1414047..1415276 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
DK876_RS06890 1415266..1416432 - 1167 WP_012775254.1 AI-2E family transporter -
DK876_RS06895 1416568..1417572 + 1005 WP_012028380.1 lactonase family protein -
DK876_RS06900 1417636..1417821 + 186 WP_002935693.1 hypothetical protein -
DK876_RS06905 1417854..1418495 - 642 WP_012775255.1 HAD family hydrolase -
DK876_RS06910 1418662..1418922 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK876_RS06915 1418924..1419145 - 222 WP_012775256.1 hypothetical protein Antitoxin
DK876_RS06920 1419455..1420762 - 1308 WP_002935704.1 phosphopyruvate hydratase -
DK876_RS06925 1420912..1421364 + 453 WP_012028381.1 DUF1694 domain-containing protein -
DK876_RS06930 1421371..1421600 - 230 Protein_1322 hypothetical protein -
DK876_RS06935 1421591..1422718 - 1128 WP_012028382.1 glycerate kinase -
DK876_RS06940 1422826..1423476 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1423913..1425115 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T106874 WP_012027435.1 NZ_CP030022:c1418922-1418662 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T106874 NZ_CP030022:c1418922-1418662 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT106874 WP_012775256.1 NZ_CP030022:c1419145-1418924 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT106874 NZ_CP030022:c1419145-1418924 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References