145627

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1422709..1423192 Replicon chromosome
Accession NZ_CP047248
Organism Streptococcus suis strain LSM178

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag GRI05_RS06935 Protein ID WP_012027435.1
Coordinates 1422709..1422969 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag GRI05_RS06940 Protein ID WP_012775256.1
Coordinates 1422971..1423192 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRI05_RS06910 1418094..1419323 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
GRI05_RS06915 1419313..1420479 - 1167 WP_012775254.1 AI-2E family transporter -
GRI05_RS06920 1420615..1421619 + 1005 WP_012028380.1 lactonase family protein -
GRI05_RS06925 1421683..1421868 + 186 WP_002935693.1 hypothetical protein -
GRI05_RS06930 1421901..1422542 - 642 WP_012775255.1 HAD family hydrolase -
GRI05_RS06935 1422709..1422969 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GRI05_RS06940 1422971..1423192 - 222 WP_012775256.1 hypothetical protein Antitoxin
GRI05_RS06945 1423502..1424809 - 1308 WP_002935704.1 phosphopyruvate hydratase -
GRI05_RS06950 1424959..1425411 + 453 WP_012028381.1 DUF1694 domain-containing protein -
GRI05_RS06955 1425418..1425647 - 230 Protein_1327 hypothetical protein -
GRI05_RS06960 1425638..1426765 - 1128 WP_012028382.1 glycerate kinase -
GRI05_RS06965 1426873..1427523 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1427960..1429162 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T145627 WP_012027435.1 NZ_CP047248:c1422969-1422709 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T145627 NZ_CP062411:2691384-2691746 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT145627 WP_012775256.1 NZ_CP047248:c1423192-1422971 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT145627 NZ_CP062411:2691217-2691387 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References