24008

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1489095..1489578 Replicon chromosome
Accession NC_012926
Organism Streptococcus suis BM407

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag SSUBM407_RS07275 Protein ID WP_012027435.1
Coordinates 1489095..1489355 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag SSUBM407_RS07280 Protein ID WP_012775256.1
Coordinates 1489357..1489578 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUBM407_RS07250 1484480..1485709 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
SSUBM407_RS07255 1485699..1486865 - 1167 WP_012775254.1 AI-2E family transporter -
SSUBM407_RS07260 1487001..1488005 + 1005 WP_012028380.1 lactonase family protein -
SSUBM407_RS07265 1488069..1488254 + 186 WP_002935693.1 hypothetical protein -
SSUBM407_RS07270 1488287..1488928 - 642 WP_012775255.1 HAD family hydrolase -
SSUBM407_RS07275 1489095..1489355 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUBM407_RS07280 1489357..1489578 - 222 WP_012775256.1 hypothetical protein Antitoxin
SSUBM407_RS07285 1489888..1491195 - 1308 WP_002935704.1 phosphopyruvate hydratase -
SSUBM407_RS07290 1491345..1491797 + 453 WP_012028381.1 DUF1694 domain-containing protein -
SSUBM407_RS07295 1491804..1492034 - 231 WP_014917285.1 hypothetical protein -
SSUBM407_RS07300 1492025..1493152 - 1128 WP_012775652.1 glycerate kinase -
SSUBM407_RS07305 1493260..1493910 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1494347..1495549 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T24008 WP_012027435.1 NC_012926:c1489355-1489095 [Streptococcus suis BM407]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T24008 NC_012926:c1489355-1489095 [Streptococcus suis BM407]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT24008 WP_012775256.1 NC_012926:c1489578-1489357 [Streptococcus suis BM407]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT24008 NC_012926:c1489578-1489357 [Streptococcus suis BM407]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References