Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1338259..1338742 Replicon chromosome
Accession NZ_LS483418
Organism Streptococcus suis strain NCTC10234

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag DQM62_RS06700 Protein ID WP_012027435.1
Coordinates 1338259..1338519 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag DQM62_RS06705 Protein ID WP_012775256.1
Coordinates 1338521..1338742 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM62_RS06675 1333644..1334873 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
DQM62_RS06680 1334863..1336029 - 1167 WP_012775254.1 AI-2E family transporter -
DQM62_RS06685 1336165..1337169 + 1005 WP_012028380.1 lactonase family protein -
DQM62_RS06690 1337233..1337418 + 186 WP_002935693.1 hypothetical protein -
DQM62_RS06695 1337451..1338092 - 642 WP_012775255.1 HAD family hydrolase -
DQM62_RS06700 1338259..1338519 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM62_RS06705 1338521..1338742 - 222 WP_012775256.1 hypothetical protein Antitoxin
DQM62_RS06710 1339052..1340359 - 1308 WP_002935704.1 phosphopyruvate hydratase -
DQM62_RS06715 1340509..1340961 + 453 WP_012028381.1 DUF1694 domain-containing protein -
DQM62_RS06720 1340968..1341198 - 231 WP_014917285.1 hypothetical protein -
DQM62_RS06725 1341189..1342316 - 1128 WP_012028382.1 glycerate kinase -
DQM62_RS06730 1342424..1343074 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1343511..1344713 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T292533 WP_012027435.1 NZ_LS483418:c1338519-1338259 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT292533 WP_012775256.1 NZ_LS483418:c1338742-1338521 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References