214295

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1406342..1406825 Replicon chromosome
Accession NZ_CP082201
Organism Streptococcus suis strain Transconjugant cAKJ18

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag K6967_RS06890 Protein ID WP_012027435.1
Coordinates 1406342..1406602 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag K6967_RS06895 Protein ID WP_012775256.1
Coordinates 1406604..1406825 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6967_RS06865 (K6967_06865) 1401727..1402956 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
K6967_RS06870 (K6967_06870) 1402946..1404112 - 1167 WP_012775254.1 AI-2E family transporter -
K6967_RS06875 (K6967_06875) 1404248..1405252 + 1005 WP_012028380.1 lactonase family protein -
K6967_RS06880 (K6967_06880) 1405316..1405501 + 186 WP_002935693.1 hypothetical protein -
K6967_RS06885 (K6967_06885) 1405534..1406175 - 642 WP_012775255.1 HAD family hydrolase -
K6967_RS06890 (K6967_06890) 1406342..1406602 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6967_RS06895 (K6967_06895) 1406604..1406825 - 222 WP_012775256.1 DUF6290 family protein Antitoxin
K6967_RS06900 (K6967_06900) 1407135..1408442 - 1308 WP_002935704.1 phosphopyruvate hydratase -
K6967_RS06905 (K6967_06905) 1408592..1409044 + 453 WP_012028381.1 DUF1694 domain-containing protein -
K6967_RS06910 (K6967_06910) 1409110..1409280 - 171 WP_014636067.1 hypothetical protein -
K6967_RS06915 (K6967_06915) 1409271..1410398 - 1128 WP_012028382.1 glycerate kinase -
K6967_RS06920 (K6967_06920) 1410506..1411156 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1411593..1412795 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T214295 WP_012027435.1 NZ_CP082201:c1406602-1406342 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T214295 NZ_CP110018:c4635234-4634977 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT214295 WP_012775256.1 NZ_CP082201:c1406825-1406604 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT214295 NZ_CP110018:c4634965-4634420 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References