182608

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1419035..1419518 Replicon chromosome
Accession NZ_CP065431
Organism Streptococcus suis strain YP20190405

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag I5W22_RS06940 Protein ID WP_012027435.1
Coordinates 1419035..1419295 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag I5W22_RS06945 Protein ID WP_012775256.1
Coordinates 1419297..1419518 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5W22_RS06915 1414420..1415649 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
I5W22_RS06920 1415639..1416805 - 1167 WP_012775254.1 AI-2E family transporter -
I5W22_RS06925 1416941..1417945 + 1005 WP_012028380.1 lactonase family protein -
I5W22_RS06930 1418009..1418194 + 186 WP_002935693.1 hypothetical protein -
I5W22_RS06935 1418227..1418868 - 642 WP_012775255.1 HAD family hydrolase -
I5W22_RS06940 1419035..1419295 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I5W22_RS06945 1419297..1419518 - 222 WP_012775256.1 hypothetical protein Antitoxin
I5W22_RS06950 1419828..1421135 - 1308 WP_002935704.1 phosphopyruvate hydratase -
I5W22_RS06955 1421285..1421737 + 453 WP_012028381.1 DUF1694 domain-containing protein -
I5W22_RS06960 1421744..1421973 - 230 Protein_1328 hypothetical protein -
I5W22_RS06965 1421964..1423091 - 1128 WP_012028382.1 glycerate kinase -
I5W22_RS06970 1423199..1423849 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1424286..1425488 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T182608 WP_012027435.1 NZ_CP065431:c1419295-1419035 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T182608 NZ_CP086510:2144415-2144518 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT182608 WP_012775256.1 NZ_CP065431:c1419518-1419297 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT182608 NZ_CP086510:c2144556-2144285 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References