262468

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1417494..1417977 Replicon chromosome
Accession NZ_CP109941
Organism Streptococcus suis strain ID38828

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag OHM51_RS06965 Protein ID WP_012027435.1
Coordinates 1417494..1417754 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag OHM51_RS06970 Protein ID WP_012775256.1
Coordinates 1417756..1417977 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM51_RS06940 (OHM51_06940) 1412879..1414108 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
OHM51_RS06945 (OHM51_06945) 1414098..1415264 - 1167 WP_012775254.1 AI-2E family transporter -
OHM51_RS06950 (OHM51_06950) 1415400..1416404 + 1005 WP_012028380.1 lactonase family protein -
OHM51_RS06955 (OHM51_06955) 1416468..1416653 + 186 WP_002935693.1 hypothetical protein -
OHM51_RS06960 (OHM51_06960) 1416686..1417327 - 642 WP_012775255.1 HAD family hydrolase -
OHM51_RS06965 (OHM51_06965) 1417494..1417754 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OHM51_RS06970 (OHM51_06970) 1417756..1417977 - 222 WP_012775256.1 DUF6290 family protein Antitoxin
OHM51_RS06975 (OHM51_06975) 1418287..1419594 - 1308 WP_002935704.1 phosphopyruvate hydratase -
OHM51_RS06980 (OHM51_06980) 1419744..1420196 + 453 WP_012028381.1 DUF1694 domain-containing protein -
OHM51_RS06985 (OHM51_06985) 1420262..1420432 - 171 WP_014636067.1 hypothetical protein -
OHM51_RS06990 (OHM51_06990) 1420423..1421550 - 1128 WP_012028382.1 glycerate kinase -
OHM51_RS06995 (OHM51_06995) 1421658..1422308 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1422745..1423947 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T262468 WP_012027435.1 NZ_CP109941:c1417754-1417494 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT262468 WP_012775256.1 NZ_CP109941:c1417977-1417756 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References