Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1350318..1350801 Replicon chromosome
Accession NZ_LR738721
Organism Streptococcus suis isolate S10

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag GPW51_RS06710 Protein ID WP_012027435.1
Coordinates 1350318..1350578 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag GPW51_RS06715 Protein ID WP_012775256.1
Coordinates 1350580..1350801 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW51_RS06685 1345703..1346932 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
GPW51_RS06690 1346922..1348088 - 1167 WP_012775254.1 AI-2E family transporter -
GPW51_RS06695 1348224..1349228 + 1005 WP_012028380.1 lactonase family protein -
GPW51_RS06700 1349292..1349477 + 186 WP_002935693.1 hypothetical protein -
GPW51_RS06705 1349510..1350151 - 642 WP_012775255.1 HAD family hydrolase -
GPW51_RS06710 1350318..1350578 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW51_RS06715 1350580..1350801 - 222 WP_012775256.1 hypothetical protein Antitoxin
GPW51_RS06720 1351111..1352418 - 1308 WP_002935704.1 phosphopyruvate hydratase -
GPW51_RS06725 1352568..1353020 + 453 WP_012028381.1 DUF1694 domain-containing protein -
GPW51_RS06730 1353027..1353256 - 230 Protein_1255 hypothetical protein -
GPW51_RS06735 1353247..1354374 - 1128 WP_012028382.1 glycerate kinase -
GPW51_RS06740 1354482..1355132 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1355569..1356771 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T288904 WP_012027435.1 NZ_LR738721:c1350578-1350318 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT288904 WP_012775256.1 NZ_LR738721:c1350801-1350580 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References