29030

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1480008..1480491 Replicon chromosome
Accession NC_020526
Organism Streptococcus suis SC070731

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag NJAUSS_RS07260 Protein ID WP_012027435.1
Coordinates 1480008..1480268 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag NJAUSS_RS07265 Protein ID WP_012775256.1
Coordinates 1480270..1480491 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NJAUSS_RS07235 1475393..1476622 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
NJAUSS_RS07240 1476612..1477778 - 1167 WP_012775254.1 AI-2E family transporter -
NJAUSS_RS07245 1477914..1478918 + 1005 WP_012028380.1 lactonase family protein -
NJAUSS_RS07250 1478982..1479167 + 186 WP_002935693.1 hypothetical protein -
NJAUSS_RS07255 1479200..1479841 - 642 WP_012775255.1 HAD family hydrolase -
NJAUSS_RS07260 1480008..1480268 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NJAUSS_RS07265 1480270..1480491 - 222 WP_012775256.1 hypothetical protein Antitoxin
NJAUSS_RS07270 1480801..1482108 - 1308 WP_002935704.1 phosphopyruvate hydratase -
NJAUSS_RS07275 1482258..1482710 + 453 WP_012028381.1 DUF1694 domain-containing protein -
NJAUSS_RS10835 1482717..1482946 - 230 Protein_1377 hypothetical protein -
NJAUSS_RS07280 1482937..1484064 - 1128 WP_012028382.1 glycerate kinase -
NJAUSS_RS07285 1484172..1484822 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1485259..1486461 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T29030 WP_012027435.1 NC_020526:c1480268-1480008 [Streptococcus suis SC070731]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T29030 NC_020526:c1480268-1480008 [Streptococcus suis SC070731]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT29030 WP_012775256.1 NC_020526:c1480491-1480270 [Streptococcus suis SC070731]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT29030 NC_020526:c1480491-1480270 [Streptococcus suis SC070731]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References