Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1476942..1477425 Replicon chromosome
Accession NC_017618
Organism Streptococcus suis JS14

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag SSUJS14_RS07290 Protein ID WP_012027435.1
Coordinates 1476942..1477202 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag SSUJS14_RS07295 Protein ID WP_012775256.1
Coordinates 1477204..1477425 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUJS14_RS07265 1472327..1473556 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
SSUJS14_RS07270 1473546..1474712 - 1167 WP_012775254.1 AI-2E family transporter -
SSUJS14_RS07275 1474848..1475852 + 1005 WP_012028380.1 lactonase family protein -
SSUJS14_RS07280 1475916..1476101 + 186 WP_002935693.1 hypothetical protein -
SSUJS14_RS07285 1476134..1476775 - 642 WP_012775255.1 HAD family hydrolase -
SSUJS14_RS07290 1476942..1477202 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUJS14_RS07295 1477204..1477425 - 222 WP_012775256.1 hypothetical protein Antitoxin
SSUJS14_RS07300 1477735..1479042 - 1308 WP_002935704.1 phosphopyruvate hydratase -
SSUJS14_RS07305 1479192..1479644 + 453 WP_012028381.1 DUF1694 domain-containing protein -
SSUJS14_RS10910 1479651..1479880 - 230 Protein_1379 hypothetical protein -
SSUJS14_RS07310 1479871..1480998 - 1128 WP_012028382.1 glycerate kinase -
SSUJS14_RS07315 1481106..1481756 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1482220..1483395 1175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T27116 WP_012027435.1 NC_017618:c1477202-1476942 [Streptococcus suis JS14]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T27116 NC_017618:c1477202-1476942 [Streptococcus suis JS14]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT27116 WP_012775256.1 NC_017618:c1477425-1477204 [Streptococcus suis JS14]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT27116 NC_017618:c1477425-1477204 [Streptococcus suis JS14]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References