214274

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1403545..1404028 Replicon chromosome
Accession NZ_CP082197
Organism Streptococcus suis strain Transconjugant cSS389

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag K6975_RS06810 Protein ID WP_012027435.1
Coordinates 1403545..1403805 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag K6975_RS06815 Protein ID WP_012775256.1
Coordinates 1403807..1404028 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6975_RS06785 (K6975_06785) 1398930..1400159 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
K6975_RS06790 (K6975_06790) 1400149..1401315 - 1167 WP_012775254.1 AI-2E family transporter -
K6975_RS06795 (K6975_06795) 1401451..1402455 + 1005 WP_012028380.1 lactonase family protein -
K6975_RS06800 (K6975_06800) 1402519..1402704 + 186 WP_002935693.1 hypothetical protein -
K6975_RS06805 (K6975_06805) 1402737..1403378 - 642 WP_012775255.1 HAD family hydrolase -
K6975_RS06810 (K6975_06810) 1403545..1403805 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6975_RS06815 (K6975_06815) 1403807..1404028 - 222 WP_012775256.1 DUF6290 family protein Antitoxin
K6975_RS06820 (K6975_06820) 1404338..1405645 - 1308 WP_002935704.1 phosphopyruvate hydratase -
K6975_RS06825 (K6975_06825) 1405795..1406247 + 453 WP_012028381.1 DUF1694 domain-containing protein -
K6975_RS06830 (K6975_06830) 1406313..1406483 - 171 WP_014636067.1 hypothetical protein -
K6975_RS06835 (K6975_06835) 1406474..1407601 - 1128 WP_012028382.1 glycerate kinase -
K6975_RS06840 (K6975_06840) 1407709..1408359 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1408796..1409998 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T214274 WP_012027435.1 NZ_CP082197:c1403805-1403545 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T214274 NZ_CP110018:c1308739-1308632 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT214274 WP_012775256.1 NZ_CP082197:c1404028-1403807 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT214274 NZ_CP110018:1308787-1308853 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References