28233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1334772..1335255 Replicon chromosome
Accession NC_018526
Organism Streptococcus suis S735

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag YYK_RS06560 Protein ID WP_012027435.1
Coordinates 1334772..1335032 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag YYK_RS06565 Protein ID WP_012775256.1
Coordinates 1335034..1335255 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YYK_RS06535 1330153..1331382 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
YYK_RS06540 1331391..1332542 - 1152 WP_014917284.1 AI-2E family transporter -
YYK_RS06545 1332678..1333682 + 1005 WP_012028380.1 lactonase family protein -
YYK_RS06550 1333746..1333931 + 186 WP_002935693.1 hypothetical protein -
YYK_RS06555 1333964..1334605 - 642 WP_012775255.1 HAD family hydrolase -
YYK_RS06560 1334772..1335032 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YYK_RS06565 1335034..1335255 - 222 WP_012775256.1 hypothetical protein Antitoxin
YYK_RS06570 1335565..1336872 - 1308 WP_002935704.1 phosphopyruvate hydratase -
YYK_RS06575 1337022..1337474 + 453 WP_012028381.1 DUF1694 domain-containing protein -
YYK_RS06580 1337481..1337711 - 231 WP_014917285.1 hypothetical protein -
YYK_RS06585 1337702..1338829 - 1128 WP_012028382.1 glycerate kinase -
YYK_RS06590 1338937..1339587 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1340024..1341226 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T28233 WP_012027435.1 NC_018526:c1335032-1334772 [Streptococcus suis S735]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T28233 NC_018526:c1335032-1334772 [Streptococcus suis S735]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT28233 WP_012775256.1 NC_018526:c1335255-1335034 [Streptococcus suis S735]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT28233 NC_018526:c1335255-1335034 [Streptococcus suis S735]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References