Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) relBE/PHD-RelE
Location 1388685..1389244 Replicon chromosome
Accession NC_000962
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name relE Uniprot ID O50461
Locus tag Rv1246c Protein ID NP_215762.1
Coordinates 1388685..1388978 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O50462
Locus tag Rv1247c Protein ID NP_215763.1
Coordinates 1388975..1389244 (-) Length 90 a.a.

Genomic Context

Rv1241Rv1242Rv1244Rv1243cRv1245cRv1246cRv1247cRv1248cRv1249c
Location: 1384278..1384538 (261 bp)
Type: Others
Protein ID: NP_215757.1
Location: 1384535..1384966 (432 bp)
Type: Others
Protein ID: NP_215758.1
Location: 1386857..1387717 (861 bp)
Type: Others
Protein ID: NP_215760.1
Location: 1384989..1386677 (1689 bp)
Type: Others
Protein ID: YP_177798.1
Location: 1387798..1388628 (831 bp)
Type: Others
Protein ID: NP_215761.1
Location: 1388685..1388978 (294 bp)
Type: Toxin
Protein ID: NP_215762.1
Location: 1388975..1389244 (270 bp)
Type: Antitoxin
Protein ID: NP_215763.1
Location: 1389357..1393052 (3696 bp)
Type: Others
Protein ID: NP_215764.2
Location: 1393194..1393982 (789 bp)
Type: Others
Protein ID: NP_215765.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Rv12411384278..1384538+261NP_215757.1antitoxin VapB33-
Rv12421384535..1384966+432NP_215758.1ribonuclease VapC33-
Rv1243c1384989..1386677-1689YP_177798.1PE-PGRS family protein PE_PGRS23-
Rv12441386857..1387717+861NP_215760.1lipoprotein LpqZ-
Rv1245c1387798..1388628-831NP_215761.1short-chain type dehydrogenase/reductase-
Rv1246c1388685..1388978-294NP_215762.1toxin RelEToxin
Rv1247c1388975..1389244-270NP_215763.1antitoxin RelBAntitoxin
Rv1248c1389357..1393052-3696NP_215764.2multifunctional 2-oxoglutarate dehydrogenase E1 component /2-oxoglutarate dehydrogenase dihydrolipoyllysine-residue succinyltransferase-
Rv1249c1393194..1393982-789NP_215765.1membrane protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T93 NP_215762.1 NC_000962:c1388978-1388685 [Mycobacterium tuberculosis H37Rv]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

>T93 NC_000962:c1388978-1388685 [Mycobacterium tuberculosis H37Rv]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT93 NP_215763.1 NC_000962:c1389244-1388975 [Mycobacterium tuberculosis H37Rv]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp

>AT93 NC_000962:c1389244-1388975 [Mycobacterium tuberculosis H37Rv]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T124Mycobacterium tuberculosis H37Rv

54.118

97.701

0.529

T6285Streptomyces cattleya NRRL 8057 = DSM 46488

31.818

100

0.322
Showing 1 to 2 of 2 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT124Mycobacterium tuberculosis H37Rv

44.186

96.629

0.427

AT130Mycobacterium tuberculosis H37Rv

35.714

94.382

0.337
Showing 1 to 2 of 2 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
AlphaFold DBO50461

Antitoxin

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Source
ID
Structure
AlphaFold DBO50462

References

(1) Min Yang et al. (2010) Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules. PloS One 5(5):e10672. [PubMed:20498855] experimental

(2) Shaleen B Korch et al. (2009) Three Mycobacterium tuberculosis Rel toxin-antitoxin modules inhibit mycobacterial growth and are expressed in infected human macrophages. Journal of Bacteriology 191(5):1618-30. [PubMed:19114484] experimental


experimental experimental literature