Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) relBE/PHD-RelE
Location 3770773..3771302 Replicon chromosome
Accession NC_000962
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name relE Uniprot ID P9WF09
Locus tag Rv3358 Protein ID NP_217875.1
Coordinates 3771045..3771302 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID P9WF25
Locus tag Rv3357 Protein ID NP_217874.1
Coordinates 3770773..3771048 (+) Length 92 a.a.

Genomic Context

Rv3354Rv3357Rv3358Rv3359Rv3360Rv3351cRv3352cRv3353cRv3355cRv3356cRv3361cRv3362cRv3363cRv3364c
Location: 3769111..3769500 (390 bp)
Type: Others
Protein ID: NP_217871.1
Location: 3770773..3771048 (276 bp)
Type: Antitoxin
Protein ID: NP_217874.1
Location: 3771045..3771302 (258 bp)
Type: Toxin
Protein ID: NP_217875.1
Location: 3771344..3772534 (1191 bp)
Type: Others
Protein ID: NP_217876.1
Location: 3772651..3773019 (369 bp)
Type: Others
Protein ID: NP_217877.1
Location: 3767346..3768140 (795 bp)
Type: Others
Protein ID: NP_217868.1
Location: 3768222..3768593 (372 bp)
Type: Others
Protein ID: NP_217869.1
Location: 3768736..3768996 (261 bp)
Type: Others
Protein ID: NP_217870.2
Location: 3769514..3769807 (294 bp)
Type: Others
Protein ID: NP_217872.1
Location: 3769804..3770649 (846 bp)
Type: Others
Protein ID: NP_217873.1
Location: 3773016..3773567 (552 bp)
Type: Others
Protein ID: NP_217878.1
Location: 3773574..3774155 (582 bp)
Type: Others
Protein ID: NP_217879.1
Location: 3774136..3774504 (369 bp)
Type: Others
Protein ID: NP_217880.1
Location: 3774482..3774874 (393 bp)
Type: Others
Protein ID: NP_217881.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Rv3351c3767346..3768140-795NP_217868.1hypothetical protein-
Rv3352c3768222..3768593-372NP_217869.1oxidoreductase-
Rv3353c3768736..3768996-261NP_217870.2hypothetical protein-
Rv33543769111..3769500+390NP_217871.1hypothetical protein-
Rv3355c3769514..3769807-294NP_217872.1integral membrane protein-
Rv3356c3769804..3770649-846NP_217873.1bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase-
Rv33573770773..3771048+276NP_217874.1antitoxin RelJAntitoxin
Rv33583771045..3771302+258NP_217875.1toxin RelKToxin
Rv33593771344..3772534+1191NP_217876.1oxidoreductase-
Rv33603772651..3773019+369NP_217877.1hypothetical protein-
Rv3361c3773016..3773567-552NP_217878.1hypothetical protein-
Rv3362c3773574..3774155-582NP_217879.1ATP/GTP-binding protein-
Rv3363c3774136..3774504-369NP_217880.1hypothetical protein-
Rv3364c3774482..3774874-393NP_217881.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T130 NP_217875.1 NC_000962:3771045-3771302 [Mycobacterium tuberculosis H37Rv]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T130 NC_000962:3771045-3771302 [Mycobacterium tuberculosis H37Rv]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT130 NP_217874.1 NC_000962:3770773-3771048 [Mycobacterium tuberculosis H37Rv]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT130 NC_000962:3770773-3771048 [Mycobacterium tuberculosis H37Rv]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T6122Streptomyces coelicolor A3(2)

59.756

97.619

0.583

T310Pseudomonas putida KT2440

54.217

97.647

0.529

T728Streptococcus pneumoniae R6

52.439

97.619

0.512

T4918Actinobacillus pleuropneumoniae serovar 3 str. JL03

51.22

96.471

0.494

T6281Streptococcus suis SC84

48.78

96.471

0.471

T1043Escherichia coli str. K-12 substr. MG1655

49.351

91.667

0.452

T6115Enterococcus faecium

48.718

91.765

0.447

T6022Enterococcus faecium

48.718

91.765

0.447

T10021Lacticaseibacillus rhamnosus 51B

47.436

91.765

0.435

T10020Lacticaseibacillus rhamnosus strain 24

47.436

91.765

0.435
Showing 1 to 10 of 19 rows
1025
 rows per page

Multiple sequence alignment    


Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT6122Streptomyces coelicolor A3(2)

70.833

82.759

0.586

AT10182Aggregatibacter actinomycetemcomitans D11S 1

57.895

90.476

0.524

AT1043Escherichia coli str. K-12 substr. MG1655

50

86.747

0.434

AT4918Actinobacillus pleuropneumoniae serovar 3 str. JL03

43.836

87.952

0.386

AT2427Staphylococcus aureus subsp. aureus NCTC 8325

38.961

92.771

0.361

AT1074Staphylococcus aureus subsp. aureus N315

38.961

92.771

0.361

AT613Staphylococcus aureus subsp. aureus MW2

38.961

92.771

0.361

AT310Pseudomonas putida KT2440

38.75

87.912

0.341

AT93Mycobacterium tuberculosis H37Rv

35.714

94.382

0.337

AT10072Edwardsiella tarda EIB202

34.722

88.889

0.309
Showing 1 to 10 of 12 rows
1025
 rows per page

Multiple sequence alignment    




Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB3OEI

Antitoxin

Loading, please wait
Source
ID
Structure
PDB3D55
PDB3CTO
PDB3OEI
AlphaFold DBP9WF25

References

(1) Shaleen B Korch et al. (2009) Three Mycobacterium tuberculosis Rel toxin-antitoxin modules inhibit mycobacterial growth and are expressed in infected human macrophages. Journal of Bacteriology 191(5):1618-30. [PubMed:19114484] experimental


experimental experimental literature