10182

Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 1647993..1648495 Replicon chromosome
Accession NC_013416
Organism Aggregatibacter actinomycetemcomitans D11S 1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D11S_RS08275 Protein ID WP_005547298.1
Coordinates 1648241..1648495 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID X2JX79
Locus tag D11S_RS08270 Protein ID WP_005547296.1
Coordinates 1647993..1648244 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D11S_RS08250 (D11S_1714) 1643290..1644483 - 1194 WP_005547286.1 hypothetical protein -
D11S_RS08255 (D11S_1715) 1644492..1645265 - 774 WP_026161168.1 glycosyltransferase family 25 protein -
D11S_RS08260 (D11S_1716) 1645399..1646931 + 1533 WP_012821073.1 polysaccharide biosynthesis protein -
D11S_RS08265 (D11S_1717) 1646928..1647884 + 957 WP_005588535.1 polysaccharide pyruvyl transferase family protein -
D11S_RS08270 (D11S_1718) 1647993..1648244 + 252 WP_005547296.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
D11S_RS08275 (D11S_1719) 1648241..1648495 + 255 WP_005547298.1 Txe/YoeB family addiction module toxin Toxin
D11S_RS08280 (D11S_1720) 1648508..1649251 + 744 WP_005542222.1 YdcF family protein -
D11S_RS08285 (D11S_1722) 1649428..1650255 + 828 Protein_1568 DNA ligase -
D11S_RS08290 (D11S_1723) 1650388..1652562 - 2175 WP_005547302.1 DNA helicase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(1-84)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9394.66 Da        Isoelectric Point: 5.0637

>T10182 WP_005547296.1 NC_013416:1648241-1648495 [Aggregatibacter actinomycetemcomitans D11S-1]
MILAWTETAWEDYLYWQQVDKKTLLRINKLIQNITRAPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Download         Length: 255 bp

>T10182 NC_013416:1648241-1648495 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGATTTTAGCTTGGACGGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGAGCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10201.71 Da        Isoelectric Point: 8.8844

>AT10182 WP_005547298.1 NC_013416:1647993-1648244 [Aggregatibacter actinomycetemcomitans D11S-1]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Download         Length: 252 bp

>AT10182 NC_013416:1647993-1648244 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGAATGTAATAAGTTATTCTGCGTTCCGTGCAGAATTAGCAACAACACTTGATCAGGTGGTTGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTTGCAGCTTACGAAGAAACGGCTTATT
TATTACGTAGTCCAAAAAATAGGGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.


Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB X2JX79

References

(1) B Schneider et al. (2018) Identification and functional characterization of type II toxin/antitoxin systems in Aggregatibacter actinomycetemcomitans. Molecular Oral Microbiology 33(3):224-233. [PubMed:29319934] experimental


experimental experimental literature