Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 1647993..1648495 Replicon chromosome
Accession NC_013416
Organism Aggregatibacter actinomycetemcomitans D11S 1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D11S_RS08275 Protein ID WP_005547298.1
Coordinates 1648241..1648495 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID X2JX79
Locus tag D11S_RS08270 Protein ID WP_005547296.1
Coordinates 1647993..1648244 (+) Length 84 a.a.

Genomic Context

D11S_RS08260D11S_RS08265D11S_RS08270D11S_RS08275D11S_RS08280D11S_RS08285D11S_RS08250D11S_RS08255D11S_RS08290
Location: 1645399..1646931 (1533 bp)
Type: Others
Protein ID: WP_012821073.1
Location: 1646928..1647884 (957 bp)
Type: Others
Protein ID: WP_005588535.1
Location: 1647993..1648244 (252 bp)
Type: Antitoxin
Protein ID: WP_005547296.1
Location: 1648241..1648495 (255 bp)
Type: Toxin
Protein ID: WP_005547298.1
Location: 1648508..1649251 (744 bp)
Type: Others
Protein ID: WP_005542222.1
Location: 1649428..1650255 (828 bp)
Type: Others
Protein ID: Protein_1568
Location: 1643290..1644483 (1194 bp)
Type: Others
Protein ID: WP_005547286.1
Location: 1644492..1645265 (774 bp)
Type: Others
Protein ID: WP_026161168.1
Location: 1650388..1652562 (2175 bp)
Type: Others
Protein ID: WP_005547302.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
D11S_RS08250 (D11S_1714)1643290..1644483-1194WP_005547286.1hypothetical protein-
D11S_RS08255 (D11S_1715)1644492..1645265-774WP_026161168.1glycosyltransferase family 25 protein-
D11S_RS08260 (D11S_1716)1645399..1646931+1533WP_012821073.1polysaccharide biosynthesis protein-
D11S_RS08265 (D11S_1717)1646928..1647884+957WP_005588535.1polysaccharide pyruvyl transferase family protein-
D11S_RS08270 (D11S_1718)1647993..1648244+252WP_005547296.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
D11S_RS08275 (D11S_1719)1648241..1648495+255WP_005547298.1Txe/YoeB family addiction module toxinToxin
D11S_RS08280 (D11S_1720)1648508..1649251+744WP_005542222.1YdcF family protein-
D11S_RS08285 (D11S_1722)1649428..1650255+828Protein_1568DNA ligase-
D11S_RS08290 (D11S_1723)1650388..1652562-2175WP_005547302.1DNA helicase II-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(1-84)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9394.66 Da        Isoelectric Point: 5.0637

>T10182 WP_005547296.1 NC_013416:1648241-1648495 [Aggregatibacter actinomycetemcomitans D11S-1]
MILAWTETAWEDYLYWQQVDKKTLLRINKLIQNITRAPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Download         Length: 255 bp

>T10182 NC_013416:1648241-1648495 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGATTTTAGCTTGGACGGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGAGCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10201.71 Da        Isoelectric Point: 8.8844

>AT10182 WP_005547298.1 NC_013416:1647993-1648244 [Aggregatibacter actinomycetemcomitans D11S-1]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Download         Length: 252 bp

>AT10182 NC_013416:1647993-1648244 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGAATGTAATAAGTTATTCTGCGTTCCGTGCAGAATTAGCAACAACACTTGATCAGGTGGTTGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTTGCAGCTTACGAAGAAACGGCTTATT
TATTACGTAGTCCAAAAAATAGGGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T1043Escherichia coli str. K-12 substr. MG1655

63.415

97.619

0.619

T4918Actinobacillus pleuropneumoniae serovar 3 str. JL03

61.905

100

0.619

T6115Enterococcus faecium

56.471

100

0.571

T6022Enterococcus faecium

56.471

100

0.571

T6281Streptococcus suis SC84

57.143

100

0.571

T10077Agrobacterium tumefaciens str. C58

53.409

100

0.56

T6122Streptomyces coelicolor A3(2)

56.098

97.619

0.548

T10021Lacticaseibacillus rhamnosus 51B

54.118

100

0.548

T6138Lactobacillus rhamnosus Lc 705

54.118

100

0.548

T6143Lactobacillus rhamnosus ATCC 8530

54.118

100

0.548
Showing 1 to 10 of 19 rows
1025
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Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT1043Escherichia coli str. K-12 substr. MG1655

54.217

100

0.542

AT310Pseudomonas putida KT2440

49.383

97.59

0.482

AT4918Actinobacillus pleuropneumoniae serovar 3 str. JL03

48.193

100

0.482

AT6122Streptomyces coelicolor A3(2)

47.436

93.976

0.446

AT130Mycobacterium tuberculosis H37Rv

45.07

85.542

0.386

AT6237Lactobacillus rhamnosus Lc 705

37.805

98.795

0.373

AT6138Lactobacillus rhamnosus Lc 705

37.805

98.795

0.373

AT6143Lactobacillus rhamnosus ATCC 8530

37.805

98.795

0.373

AT10020Lacticaseibacillus rhamnosus strain 24

37.805

98.795

0.373

AT10021Lacticaseibacillus rhamnosus 51B

37.805

98.795

0.373
Showing 1 to 10 of 14 rows
1025
 rows per page

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBX2JX79

References

(1) B Schneider et al. (2018) Identification and functional characterization of type II toxin/antitoxin systems in Aggregatibacter actinomycetemcomitans. Molecular Oral Microbiology 33(3):224-233. [PubMed:29319934] experimental


experimental experimental literature