Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/PHD-RelE
Location 1566450..1567001 Replicon chromosome
Accession NC_003098
Organism Streptococcus pneumoniae R6

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag spr1585 Protein ID 15903627
Coordinates 1566450..1566704 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DNR2
Locus tag spr1586 Protein ID 15903628
Coordinates 1566708..1566962 (-) Length 85 a.a.

Genomic Context

SPR_RS07845SPR_RS07850SPR_RS07855SPR_RS07860SPR_RS07865SPR_RS07870SPR_RS07875SPR_RS07880SPR_RS07885SPR_RS07890SPR_RS07895SPR_RS07900
Location: 1563551..1563865 (315 bp)
Type: Others
Protein ID: WP_000979235.1
Location: 1563890..1564516 (627 bp)
Type: Others
Protein ID: WP_000775044.1
Location: 1564646..1566259 (1614 bp)
Type: Others
Protein ID: WP_000404940.1
Location: 1566450..1566704 (255 bp)
Type: Toxin
Protein ID: WP_000924721.1
Location: 1566708..1566962 (255 bp)
Type: Antitoxin
Protein ID: WP_000388572.1
Location: 1567200..1568297 (1098 bp)
Type: Others
Protein ID: WP_000156355.1
Location: 1568307..1569053 (747 bp)
Type: Others
Protein ID: WP_000605157.1
Location: 1569156..1569509 (354 bp)
Type: Others
Protein ID: WP_001003001.1
Location: 1569522..1570022 (501 bp)
Type: Others
Protein ID: WP_000844717.1
Location: 1570023..1570616 (594 bp)
Type: Others
Protein ID: WP_000121655.1
Location: 1570616..1571245 (630 bp)
Type: Others
Protein ID: WP_000151313.1
Location: 1571297..1571608 (312 bp)
Type: Others
Protein ID: WP_000060169.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SPR_RS07845 (spr1582)1563551..1563865-315WP_000979235.1DNA-directed RNA polymerase subunit omega-
SPR_RS07850 (spr1583)1563890..1564516-627WP_000775044.1guanylate kinase-
SPR_RS07855 (spr1584)1564646..1566259-1614WP_000404940.1ribonuclease Y-
SPR_RS07860 (spr1585)1566450..1566704-255WP_000924721.1Txe/YoeB family addiction module toxinToxin
SPR_RS07865 (spr1586)1566708..1566962-255WP_000388572.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
SPR_RS07870 (spr1587)1567200..1568297-1098WP_000156355.1nucleotidyltransferase-
SPR_RS07875 (spr1588)1568307..1569053-747WP_000605157.1class I SAM-dependent methyltransferase-
SPR_RS07880 (spr1589)1569156..1569509-354WP_001003001.1ribosome silencing factor-
SPR_RS07885 (spr1590)1569522..1570022-501WP_000844717.1cysteine hydrolase-
SPR_RS07890 (spr1591)1570023..1570616-594WP_000121655.1bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK-
SPR_RS07895 (spr1592)1570616..1571245-630WP_000151313.1nicotinate-nucleotide adenylyltransferase-
SPR_RS07900 (spr1593)1571297..1571608-312WP_000060169.1ribosome assembly RNA-binding protein YhbY-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T728 15903627 NC_003098:c1566704-1566450 [Streptococcus pneumoniae R6]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T728 NC_003098:c1566704-1566450 [Streptococcus pneumoniae R6]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT728 15903628 NC_003098:c1566962-1566708 [Streptococcus pneumoniae R6]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT728 NC_003098:c1566962-1566708 [Streptococcus pneumoniae R6]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTACGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T6281Streptococcus suis SC84

75

100

0.75

T6115Enterococcus faecium

55.294

100

0.56

T10021Lacticaseibacillus rhamnosus 51B

55.294

100

0.56

T10020Lacticaseibacillus rhamnosus strain 24

55.294

100

0.56

T6237Lactobacillus rhamnosus Lc 705

55.294

100

0.56

T6022Enterococcus faecium

55.294

100

0.56

T6138Lactobacillus rhamnosus Lc 705

55.294

100

0.56

T6143Lactobacillus rhamnosus ATCC 8530

55.294

100

0.56

T4918Actinobacillus pleuropneumoniae serovar 3 str. JL03

55.952

100

0.56

T310Pseudomonas putida KT2440

52.439

97.619

0.512
Showing 1 to 10 of 18 rows
1025
 rows per page

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT6281Streptococcus suis SC84

79.487

92.857

0.738

AT10182Aggregatibacter actinomycetemcomitans D11S 1

54.762

100

0.548

AT6138Lactobacillus rhamnosus Lc 705

47.5

95.238

0.452

AT6143Lactobacillus rhamnosus ATCC 8530

47.5

95.238

0.452

AT6237Lactobacillus rhamnosus Lc 705

47.5

95.238

0.452

AT10020Lacticaseibacillus rhamnosus strain 24

47.5

95.238

0.452

AT10021Lacticaseibacillus rhamnosus 51B

47.5

95.238

0.452

AT6115Enterococcus faecium

46.25

95.238

0.44

AT6022Enterococcus faecium

46.25

95.238

0.44

AT613Staphylococcus aureus subsp. aureus MW2

34.722

86.747

0.301
Showing 1 to 10 of 12 rows
1025
 rows per page

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ8DNR3

Antitoxin

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Source
ID
Structure
AlphaFold DBQ8DNR2

References

(1) Wai Ting Chan et al. (2018) The Streptococcus pneumoniaeyefM-yoeB and relBE Toxin-Antitoxin Operons Participate in Oxidative Stress and Biofilm Formation. Toxins 10(9):378. [PubMed:30231554] experimental


experimental experimental literature