Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/PHD-RelE
Location 2466001..2466518 Replicon chromosome
Accession NC_002745
Organism Staphylococcus aureus subsp. aureus N315

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag SA_RS12585 Protein ID WP_000113265.1
Coordinates 2466001..2466267 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SA_RS12590 Protein ID WP_000584499.1
Coordinates 2466267..2466518 (-) Length 84 a.a.

Genomic Context

SA_RS12610SA_RS12560SA_RS12565SA_RS12570SA_RS12575SA_RS12580SA_RS14935SA_RS12585SA_RS12590SA_RS12595SA_RS12600SA_RS12605SA_RS12615SA_RS12620
Location: 2468026..2469276 (1251 bp)
Type: Others
Protein ID: WP_001012225.1
Location: 2461429..2461965 (537 bp)
Type: Others
Protein ID: WP_000169317.1
Location: 2462199..2463023 (825 bp)
Type: Others
Protein ID: WP_000572038.1
Location: 2463240..2463422 (183 bp)
Type: Others
Protein ID: WP_000230292.1
Location: 2463506..2463973 (468 bp)
Type: Others
Protein ID: WP_000153347.1
Location: 2464159..2465706 (1548 bp)
Type: Others
Protein ID: WP_000727772.1
Location: 2465895..2465966 (72 bp)
Type: Others
Protein ID: Protein_2358
Location: 2466001..2466267 (267 bp)
Type: Toxin
Protein ID: WP_000113265.1
Location: 2466267..2466518 (252 bp)
Type: Antitoxin
Protein ID: WP_000584499.1
Location: 2466683..2466784 (102 bp)
Type: Others
Protein ID: Protein_2361
Location: 2466791..2467390 (600 bp)
Type: Others
Protein ID: WP_000162810.1
Location: 2467409..2467771 (363 bp)
Type: Others
Protein ID: WP_000819843.1
Location: 2469373..2470104 (732 bp)
Type: Others
Protein ID: WP_000615461.1
Location: 2470101..2470820 (720 bp)
Type: Others
Protein ID: WP_000479576.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SA_RS12560 (SA2190)2461429..2461965-537WP_000169317.1GNAT family N-acetyltransferase-
SA_RS12565 (SA2191)2462199..2463023-825WP_000572038.1formate/nitrite transporter family protein-
SA_RS12570 (SA2192)2463240..2463422-183WP_000230292.1hypothetical protein-
SA_RS12575 (SA2193)2463506..2463973-468WP_000153347.1SRPBCC domain-containing protein-
SA_RS12580 (SA2194)2464159..2465706-1548WP_000727772.1zinc ABC transporter substrate-binding lipoprotein AdcA-
SA_RS149352465895..2465966-72Protein_2358hypothetical protein-
SA_RS12585 (SA2195)2466001..2466267-267WP_000113265.1Txe/YoeB family addiction module toxinToxin
SA_RS12590 (SA2196)2466267..2466518-252WP_000584499.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
SA_RS125952466683..2466784-102Protein_2361hypothetical protein-
SA_RS12600 (SA2197)2466791..2467390-600WP_000162810.1DsbA family protein-
SA_RS12605 (SA2198)2467409..2467771-363WP_000819843.1DUF4467 domain-containing protein-
SA_RS12610 (SA2199)2468026..2469276+1251WP_001012225.1FemA/FemB family glycyltransferase FmhA-
SA_RS12615 (SA2200)2469373..2470104-732WP_000615461.1amino acid ABC transporter ATP-binding protein-
SA_RS126202470101..2470820-720WP_000479576.1amino acid ABC transporter permease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T1074 WP_000113265.1 NC_002745:c2466267-2466001 [Staphylococcus aureus subsp. aureus N315]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T1074 NC_002745:c2466267-2466001 [Staphylococcus aureus subsp. aureus N315]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT1074 WP_000584499.1 NC_002745:c2466518-2466267 [Staphylococcus aureus subsp. aureus N315]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT1074 NC_002745:c2466518-2466267 [Staphylococcus aureus subsp. aureus N315]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T2427Staphylococcus aureus subsp. aureus NCTC 8325

98.864

100

0.989

T613Staphylococcus aureus subsp. aureus MW2

98.864

100

0.989

T4918Actinobacillus pleuropneumoniae serovar 3 str. JL03

54.118

98.837

0.535

T1043Escherichia coli str. K-12 substr. MG1655

51.765

100

0.524

T6022Enterococcus faecium

50.602

97.647

0.494

T6115Enterococcus faecium

50.602

97.647

0.494

T10021Lacticaseibacillus rhamnosus 51B

46.988

96.512

0.453

T10020Lacticaseibacillus rhamnosus strain 24

46.988

96.512

0.453

T6138Lactobacillus rhamnosus Lc 705

46.988

96.512

0.453

T6143Lactobacillus rhamnosus ATCC 8530

46.988

96.512

0.453
Showing 1 to 10 of 19 rows
1025
 rows per page

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT613Staphylococcus aureus subsp. aureus MW2

100

100

1

AT2427Staphylococcus aureus subsp. aureus NCTC 8325

100

100

1

AT10182Aggregatibacter actinomycetemcomitans D11S 1

49.398

98.81

0.488

AT1043Escherichia coli str. K-12 substr. MG1655

44.156

92.771

0.41

AT6122Streptomyces coelicolor A3(2)

42.667

90.361

0.386

AT310Pseudomonas putida KT2440

38.554

100

0.386

AT10021Lacticaseibacillus rhamnosus 51B

42.466

87.952

0.373

AT6138Lactobacillus rhamnosus Lc 705

42.466

87.952

0.373

AT6143Lactobacillus rhamnosus ATCC 8530

42.466

87.952

0.373

AT6237Lactobacillus rhamnosus Lc 705

42.466

87.952

0.373
Showing 1 to 10 of 18 rows
1025
 rows per page

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
PDB7BWF

Antitoxin

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Source
ID
Structure
PDB6L8G
PDB6L8F
PDB7BWF
PDB6L8E
AlphaFold DBT1YB60

References

(1) Niles P Donegan et al. (2010) Proteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcus aureus. Journal of Bacteriology 192(5):1416-22. [PubMed:20038589] experimental

(2) Hyun-Jong Eun et al. (2020) Crystal structure of the YoeBSa1-YefMSa1 complex from Staphylococcus aureus. Biochemical And Biophysical Research Communications 527(1):264-269. [PubMed:32446378] 3D_structure


experimental experimental literature
3D_structure protein structure literature