Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/(antitoxin)
Location 1914763..1915282 Replicon chromosome
Accession NC_012924
Organism Streptococcus suis SC84

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag SSUSC84_RS09420 Protein ID WP_012775363.1
Coordinates 1914763..1915020 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag SSUSC84_RS09425 Protein ID WP_002939010.1
Coordinates 1915022..1915282 (-) Length 87 a.a.

Genomic Context

SSUSC84_RS09405SSUSC84_RS09410SSUSC84_RS09415SSUSC84_RS09420SSUSC84_RS09425SSUSC84_RS09430SSUSC84_RS09435SSUSC84_RS09440SSUSC84_RS09445SSUSC84_RS09450SSUSC84_RS09455SSUSC84_RS09460SSUSC84_RS09465
Location: 1911232..1912962 (1731 bp)
Type: Others
Protein ID: WP_012775361.1
Location: 1913327..1914235 (909 bp)
Type: Others
Protein ID: WP_012027884.1
Location: 1914219..1914749 (531 bp)
Type: Others
Protein ID: WP_009910909.1
Location: 1914763..1915020 (258 bp)
Type: Toxin
Protein ID: WP_012775363.1
Location: 1915022..1915282 (261 bp)
Type: Antitoxin
Protein ID: WP_002939010.1
Location: 1915358..1915813 (456 bp)
Type: Others
Protein ID: WP_012028534.1
Location: 1915820..1916149 (330 bp)
Type: Others
Protein ID: WP_012775364.1
Location: 1916139..1916426 (288 bp)
Type: Others
Protein ID: WP_012028535.1
Location: 1916524..1916892 (369 bp)
Type: Others
Protein ID: WP_012775365.1
Location: 1916885..1917454 (570 bp)
Type: Others
Protein ID: WP_012775366.1
Location: 1917438..1918220 (783 bp)
Type: Others
Protein ID: WP_012028536.1
Location: 1918327..1918464 (138 bp)
Type: Others
Protein ID: WP_002939016.1
Location: 1918632..1919627 (996 bp)
Type: Others
Protein ID: WP_012775367.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SSUSC84_RS09405 (SSUSC84_1814)1911232..1912962-1731WP_012775361.1membrane protein-
SSUSC84_RS09410 (SSUSC84_1815)1913327..1914235-909WP_012027884.116S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA-
SSUSC84_RS09415 (SSUSC84_1816)1914219..1914749-531WP_009910909.1DUF1697 domain-containing protein-
SSUSC84_RS09420 (SSUSC84_1817)1914763..1915020-258WP_012775363.1Txe/YoeB family addiction module toxinToxin
SSUSC84_RS09425 (SSUSC84_1818)1915022..1915282-261WP_002939010.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
SSUSC84_RS09430 (SSUSC84_1819)1915358..1915813-456WP_012028534.18-oxo-dGTP diphosphatase-
SSUSC84_RS09435 (SSUSC84_1820)1915820..1916149-330WP_012775364.1type II toxin-antitoxin system RelE/ParE family toxin-
SSUSC84_RS09440 (SSUSC84_1821)1916139..1916426-288WP_012028535.1hypothetical protein-
SSUSC84_RS09445 (SSUSC84_1822)1916524..1916892-369WP_012775365.1hypothetical protein-
SSUSC84_RS09450 (SSUSC84_1823)1916885..1917454-570WP_012775366.1ribonuclease M5-
SSUSC84_RS09455 (SSUSC84_1824)1917438..1918220-783WP_012028536.1TatD family hydrolase-
SSUSC84_RS09460 (SSUSC84_1825)1918327..1918464-138WP_002939016.150S ribosomal protein L34-
SSUSC84_RS09465 (SSUSC84_1826)1918632..1919627-996WP_012775367.1protein jag-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island--1874993..191822043227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T6281 WP_012775363.1 NC_012924:c1915020-1914763 [Streptococcus suis SC84]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T6281 NC_012924:c1915020-1914763 [Streptococcus suis SC84]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCCAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT6281 WP_002939010.1 NC_012924:c1915282-1915022 [Streptococcus suis SC84]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT6281 NC_012924:c1915282-1915022 [Streptococcus suis SC84]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T728Streptococcus pneumoniae R6

75

100

0.75

T4918Actinobacillus pleuropneumoniae serovar 3 str. JL03

57.143

98.824

0.565

T6022Enterococcus faecium

58.025

95.294

0.553

T6115Enterococcus faecium

58.025

95.294

0.553

T10021Lacticaseibacillus rhamnosus 51B

55.556

95.294

0.529

T6138Lactobacillus rhamnosus Lc 705

55.556

95.294

0.529

T6143Lactobacillus rhamnosus ATCC 8530

55.556

95.294

0.529

T6237Lactobacillus rhamnosus Lc 705

55.556

95.294

0.529

T10020Lacticaseibacillus rhamnosus strain 24

55.556

95.294

0.529

T6122Streptomyces coelicolor A3(2)

51.22

97.619

0.5
Showing 1 to 10 of 18 rows
1025
 rows per page

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT728Streptococcus pneumoniae R6

79.487

92.857

0.738

AT10182Aggregatibacter actinomycetemcomitans D11S 1

57.143

100

0.571

AT6115Enterococcus faecium

45.238

97.674

0.442

AT6022Enterococcus faecium

45.238

97.674

0.442

AT6143Lactobacillus rhamnosus ATCC 8530

40.964

96.512

0.395

AT6138Lactobacillus rhamnosus Lc 705

40.964

96.512

0.395

AT6237Lactobacillus rhamnosus Lc 705

40.964

96.512

0.395

AT10021Lacticaseibacillus rhamnosus 51B

40.964

96.512

0.395

AT10020Lacticaseibacillus rhamnosus strain 24

40.964

96.512

0.395

AT4918Actinobacillus pleuropneumoniae serovar 3 str. JL03

33.333

100

0.337
Showing 1 to 10 of 10 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2K1SXY6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0K2E7Z9

References

(1) Chengkun Zheng et al. (2015) Identification and characterization of the chromosomal yefM-yoeB toxin-antitoxin system of Streptococcus suis. Scientific Reports 5:13125. [PubMed:26272287] experimental


experimental experimental literature