167310

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1862807..1863413 Replicon chromosome
Accession NZ_CP058742
Organism Streptococcus suis strain 10

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag SSU10_RS09180 Protein ID WP_012775364.1
Coordinates 1862807..1863136 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag SSU10_RS09185 Protein ID WP_012028535.1
Coordinates 1863126..1863413 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSU10_RS09150 1858219..1859949 - 1731 WP_012775361.1 membrane protein -
SSU10_RS09155 1860314..1861222 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
SSU10_RS09160 1861206..1861736 - 531 WP_009910909.1 DUF1697 domain-containing protein -
SSU10_RS09165 1861750..1862007 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
SSU10_RS09170 1862009..1862269 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
SSU10_RS09175 1862345..1862800 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
SSU10_RS09180 1862807..1863136 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSU10_RS09185 1863126..1863413 - 288 WP_012028535.1 hypothetical protein Antitoxin
SSU10_RS09190 1863511..1863879 - 369 WP_012775453.1 hypothetical protein -
SSU10_RS09195 1863872..1864441 - 570 WP_012775366.1 ribonuclease M5 -
SSU10_RS09200 1864425..1865207 - 783 WP_012028536.1 TatD family hydrolase -
SSU10_RS09205 1865314..1865451 - 138 WP_002939016.1 50S ribosomal protein L34 -
SSU10_RS09210 1865619..1866614 - 996 WP_012775367.1 protein jag -
SSU10_RS09215 1866634..1867446 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
SSU10_RS09220 1867430..1867789 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1821980..1865207 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T167310 WP_012775364.1 NZ_CP058742:c1863136-1862807 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T167310 NZ_CP075112:c4289909-4289418 [Salmonella enterica subsp. enterica serovar Corvallis]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGAGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT167310 WP_012028535.1 NZ_CP058742:c1863413-1863126 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT167310 NZ_CP075112:c4290199-4289906 [Salmonella enterica subsp. enterica serovar Corvallis]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATCGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References