46538

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1913764..1914283 Replicon chromosome
Accession NZ_CP007497
Organism Streptococcus suis strain ZY05719 isolate diseased pig

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag ZY05719_RS09470 Protein ID WP_012775363.1
Coordinates 1913764..1914021 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag ZY05719_RS09475 Protein ID WP_002939010.1
Coordinates 1914023..1914283 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ZY05719_RS09455 (ZY05719_09500) 1910233..1911963 - 1731 WP_012775361.1 membrane protein -
ZY05719_RS09460 (ZY05719_09505) 1912328..1913236 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
ZY05719_RS09465 (ZY05719_09510) 1913220..1913750 - 531 WP_009910909.1 DUF1697 domain-containing protein -
ZY05719_RS09470 (ZY05719_09515) 1913764..1914021 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
ZY05719_RS09475 (ZY05719_09520) 1914023..1914283 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ZY05719_RS09480 (ZY05719_09525) 1914359..1914814 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
ZY05719_RS09485 (ZY05719_09530) 1914821..1915150 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
ZY05719_RS09490 (ZY05719_09535) 1915140..1915427 - 288 WP_012028535.1 hypothetical protein -
ZY05719_RS09495 (ZY05719_09540) 1915525..1915893 - 369 WP_012775365.1 hypothetical protein -
ZY05719_RS09500 (ZY05719_09545) 1915886..1916455 - 570 WP_012775366.1 ribonuclease M5 -
ZY05719_RS09505 (ZY05719_09550) 1916439..1917221 - 783 WP_012028536.1 TatD family hydrolase -
ZY05719_RS09510 (ZY05719_09555) 1917328..1917465 - 138 WP_002939016.1 50S ribosomal protein L34 -
ZY05719_RS09515 (ZY05719_09560) 1917633..1918628 - 996 WP_012775367.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1873994..1917221 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T46538 WP_012775363.1 NZ_CP007497:c1914021-1913764 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T46538 NZ_CP007497:c1914021-1913764 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCCAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT46538 WP_002939010.1 NZ_CP007497:c1914283-1914023 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT46538 NZ_CP007497:c1914283-1914023 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References