214276

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1880596..1881202 Replicon chromosome
Accession NZ_CP082197
Organism Streptococcus suis strain Transconjugant cSS389

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag K6975_RS09165 Protein ID WP_012775364.1
Coordinates 1880596..1880925 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag K6975_RS09170 Protein ID WP_012028535.1
Coordinates 1880915..1881202 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6975_RS09135 (K6975_09135) 1876008..1877738 - 1731 WP_012775361.1 membrane protein -
K6975_RS09140 (K6975_09140) 1878103..1878975 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
K6975_RS09145 (K6975_09145) 1878995..1879525 - 531 WP_009910909.1 DUF1697 domain-containing protein -
K6975_RS09150 (K6975_09150) 1879539..1879796 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
K6975_RS09155 (K6975_09155) 1879798..1880058 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6975_RS09160 (K6975_09160) 1880134..1880589 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
K6975_RS09165 (K6975_09165) 1880596..1880925 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6975_RS09170 (K6975_09170) 1880915..1881202 - 288 WP_012028535.1 hypothetical protein Antitoxin
K6975_RS09175 (K6975_09175) 1881300..1881668 - 369 WP_012775453.1 hypothetical protein -
K6975_RS09180 (K6975_09180) 1881661..1882230 - 570 WP_012775366.1 ribonuclease M5 -
K6975_RS09185 (K6975_09185) 1882214..1882996 - 783 WP_012028536.1 TatD family hydrolase -
K6975_RS09190 (K6975_09190) 1883103..1883240 - 138 WP_002939016.1 50S ribosomal protein L34 -
K6975_RS09195 (K6975_09195) 1883408..1884403 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -
K6975_RS09200 (K6975_09200) 1884423..1885235 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
K6975_RS09205 (K6975_09205) 1885219..1885578 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1839769..1882996 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T214276 WP_012775364.1 NZ_CP082197:c1880925-1880596 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T214276 NZ_CP110018:c1309809-1309702 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT214276 WP_012028535.1 NZ_CP082197:c1881202-1880915 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT214276 NZ_CP110018:1309856-1309922 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References