Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/- |
| Location | 1915820..1916426 | Replicon | chromosome |
| Accession | NC_012924 | ||
| Organism | Streptococcus suis SC84 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A0Z8ZB64 |
| Locus tag | SSUSC84_RS09435 | Protein ID | WP_012775364.1 |
| Coordinates | 1915820..1916149 (-) | Length | 110 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | D5AKB4 |
| Locus tag | SSUSC84_RS09440 | Protein ID | WP_012028535.1 |
| Coordinates | 1916139..1916426 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SSUSC84_RS09405 (SSUSC84_1814) | 1911232..1912962 | - | 1731 | WP_012775361.1 | membrane protein | - |
| SSUSC84_RS09410 (SSUSC84_1815) | 1913327..1914235 | - | 909 | WP_012027884.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
| SSUSC84_RS09415 (SSUSC84_1816) | 1914219..1914749 | - | 531 | WP_009910909.1 | DUF1697 domain-containing protein | - |
| SSUSC84_RS09420 (SSUSC84_1817) | 1914763..1915020 | - | 258 | WP_012775363.1 | Txe/YoeB family addiction module toxin | - |
| SSUSC84_RS09425 (SSUSC84_1818) | 1915022..1915282 | - | 261 | WP_002939010.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| SSUSC84_RS09430 (SSUSC84_1819) | 1915358..1915813 | - | 456 | WP_012028534.1 | 8-oxo-dGTP diphosphatase | - |
| SSUSC84_RS09435 (SSUSC84_1820) | 1915820..1916149 | - | 330 | WP_012775364.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| SSUSC84_RS09440 (SSUSC84_1821) | 1916139..1916426 | - | 288 | WP_012028535.1 | hypothetical protein | Antitoxin |
| SSUSC84_RS09445 (SSUSC84_1822) | 1916524..1916892 | - | 369 | WP_012775365.1 | hypothetical protein | - |
| SSUSC84_RS09450 (SSUSC84_1823) | 1916885..1917454 | - | 570 | WP_012775366.1 | ribonuclease M5 | - |
| SSUSC84_RS09455 (SSUSC84_1824) | 1917438..1918220 | - | 783 | WP_012028536.1 | TatD family hydrolase | - |
| SSUSC84_RS09460 (SSUSC84_1825) | 1918327..1918464 | - | 138 | WP_002939016.1 | 50S ribosomal protein L34 | - |
| SSUSC84_RS09465 (SSUSC84_1826) | 1918632..1919627 | - | 996 | WP_012775367.1 | protein jag | - |
| SSUSC84_RS09470 (SSUSC84_1827) | 1919647..1920459 | - | 813 | WP_012027897.1 | YidC/Oxa1 family membrane protein insertase | - |
| SSUSC84_RS09475 (SSUSC84_1828) | 1920443..1920802 | - | 360 | WP_004194560.1 | ribonuclease P protein component | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | - | 1874993..1918220 | 43227 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12562.52 Da Isoelectric Point: 7.1991
>T10159 WP_012775364.1 NC_012924:c1916149-1915820 [Streptococcus suis SC84]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK
Download Length: 330 bp
>T10159 NC_012924:c1916149-1915820 [Streptococcus suis SC84]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10892.43 Da Isoelectric Point: 4.3464
>AT10159 WP_012028535.1 NC_012924:c1916426-1916139 [Streptococcus suis SC84]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI
Download Length: 288 bp
>AT10159 NC_012924:c1916426-1916139 [Streptococcus suis SC84]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Z8ZB64 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Z9A6F4 |
References
(1) Jiali Xu et al. (2018) Identification of Three Type II Toxin-Antitoxin Systems in Streptococcus suis Serotype 2. Toxins 10(11):467. [PubMed:30428568]