Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RelB(antitoxin) |
Location | 1882841..1883447 | Replicon | chromosome |
Accession | NZ_CP082200 | ||
Organism | Streptococcus suis strain Transconjugant cDY107 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A0Z8ZB64 |
Locus tag | K6971_RS09245 | Protein ID | WP_012775364.1 |
Coordinates | 1882841..1883170 (-) | Length | 110 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | D5AKB4 |
Locus tag | K6971_RS09250 | Protein ID | WP_012028535.1 |
Coordinates | 1883160..1883447 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K6971_RS09215 (K6971_09215) | 1878253..1879983 | - | 1731 | WP_012775361.1 | membrane protein | - |
K6971_RS09220 (K6971_09220) | 1880348..1881220 | - | 873 | WP_012775362.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
K6971_RS09225 (K6971_09225) | 1881240..1881770 | - | 531 | WP_009910909.1 | DUF1697 domain-containing protein | - |
K6971_RS09230 (K6971_09230) | 1881784..1882041 | - | 258 | WP_012775363.1 | Txe/YoeB family addiction module toxin | - |
K6971_RS09235 (K6971_09235) | 1882043..1882303 | - | 261 | WP_002939010.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
K6971_RS09240 (K6971_09240) | 1882379..1882834 | - | 456 | WP_012028534.1 | 8-oxo-dGTP diphosphatase | - |
K6971_RS09245 (K6971_09245) | 1882841..1883170 | - | 330 | WP_012775364.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
K6971_RS09250 (K6971_09250) | 1883160..1883447 | - | 288 | WP_012028535.1 | hypothetical protein | Antitoxin |
K6971_RS09255 (K6971_09255) | 1883545..1883913 | - | 369 | WP_012775453.1 | hypothetical protein | - |
K6971_RS09260 (K6971_09260) | 1883906..1884475 | - | 570 | WP_012775366.1 | ribonuclease M5 | - |
K6971_RS09265 (K6971_09265) | 1884459..1885241 | - | 783 | WP_012028536.1 | TatD family hydrolase | - |
K6971_RS09270 (K6971_09270) | 1885348..1885485 | - | 138 | WP_002939016.1 | 50S ribosomal protein L34 | - |
K6971_RS09275 (K6971_09275) | 1885653..1886648 | - | 996 | WP_012775367.1 | RNA-binding cell elongation regulator Jag/EloR | - |
K6971_RS09280 (K6971_09280) | 1886668..1887480 | - | 813 | WP_012027897.1 | YidC/Oxa1 family membrane protein insertase | - |
K6971_RS09285 (K6971_09285) | 1887464..1887823 | - | 360 | WP_004194560.1 | ribonuclease P protein component | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 1842014..1885241 | 43227 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12562.52 Da Isoelectric Point: 7.1991
>T214292 WP_012775364.1 NZ_CP082200:c1883170-1882841 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK
Download Length: 330 bp
>T214292 NZ_CP110018:c3797204-3797097 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10892.43 Da Isoelectric Point: 4.3464
>AT214292 WP_012028535.1 NZ_CP082200:c1883447-1883160 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI
Download Length: 288 bp
>AT214292 NZ_CP110018:3797252-3797318 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z8ZB64 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z9A6F4 |