64292

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1886794..1887313 Replicon chromosome
Accession NZ_CP016175
Organism Streptococcus suis strain LSM102

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag A9494_RS09520 Protein ID WP_012775363.1
Coordinates 1886794..1887051 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag A9494_RS09525 Protein ID WP_002939010.1
Coordinates 1887053..1887313 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9494_RS09505 1883263..1884993 - 1731 WP_012775361.1 membrane protein -
A9494_RS09510 1885358..1886266 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
A9494_RS09515 1886250..1886780 - 531 WP_009910909.1 DUF1697 domain-containing protein -
A9494_RS09520 1886794..1887051 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
A9494_RS09525 1887053..1887313 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A9494_RS09530 1887389..1887844 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
A9494_RS09535 1887851..1888180 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
A9494_RS09540 1888170..1888457 - 288 WP_012028535.1 hypothetical protein -
A9494_RS09545 1888555..1888923 - 369 WP_012775453.1 hypothetical protein -
A9494_RS09550 1888916..1889485 - 570 WP_012775366.1 ribonuclease M5 -
A9494_RS09555 1889469..1890251 - 783 WP_012028536.1 TatD family hydrolase -
A9494_RS09560 1890358..1890495 - 138 WP_002939016.1 50S ribosomal protein L34 -
A9494_RS09565 1890663..1891658 - 996 WP_012775367.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1847024..1890251 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T64292 WP_012775363.1 NZ_CP016175:c1887051-1886794 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T64292 NZ_CP016175:c1887051-1886794 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCCAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT64292 WP_002939010.1 NZ_CP016175:c1887313-1887053 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT64292 NZ_CP016175:c1887313-1887053 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References