28235

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1800728..1801334 Replicon chromosome
Accession NC_018526
Organism Streptococcus suis S735

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag YYK_RS08875 Protein ID WP_012775364.1
Coordinates 1800728..1801057 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag YYK_RS08880 Protein ID WP_012028535.1
Coordinates 1801047..1801334 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YYK_RS08845 1796140..1797870 - 1731 WP_012775361.1 membrane protein -
YYK_RS08850 1798235..1799143 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
YYK_RS08855 1799127..1799657 - 531 WP_009910909.1 DUF1697 domain-containing protein -
YYK_RS08860 1799671..1799928 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
YYK_RS08865 1799930..1800190 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
YYK_RS08870 1800266..1800721 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
YYK_RS08875 1800728..1801057 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YYK_RS08880 1801047..1801334 - 288 WP_012028535.1 hypothetical protein Antitoxin
YYK_RS08885 1801432..1801800 - 369 WP_014917322.1 hypothetical protein -
YYK_RS08890 1801793..1802362 - 570 WP_012775700.1 ribonuclease M5 -
YYK_RS08895 1802346..1803128 - 783 WP_012028536.1 TatD family hydrolase -
YYK_RS08900 1803235..1803372 - 138 WP_002939016.1 50S ribosomal protein L34 -
YYK_RS08905 1803540..1804535 - 996 WP_012775367.1 protein jag -
YYK_RS08910 1804555..1805367 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
YYK_RS08915 1805351..1805710 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1759893..1803128 43235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T28235 WP_012775364.1 NC_018526:c1801057-1800728 [Streptococcus suis S735]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T28235 NC_018526:c1801057-1800728 [Streptococcus suis S735]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTGGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT28235 WP_012028535.1 NC_018526:c1801334-1801047 [Streptococcus suis S735]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT28235 NC_018526:c1801334-1801047 [Streptococcus suis S735]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References