Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1881784..1882303 Replicon chromosome
Accession NZ_CP082200
Organism Streptococcus suis strain Transconjugant cDY107

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag K6971_RS09230 Protein ID WP_012775363.1
Coordinates 1881784..1882041 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag K6971_RS09235 Protein ID WP_002939010.1
Coordinates 1882043..1882303 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6971_RS09215 (K6971_09215) 1878253..1879983 - 1731 WP_012775361.1 membrane protein -
K6971_RS09220 (K6971_09220) 1880348..1881220 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
K6971_RS09225 (K6971_09225) 1881240..1881770 - 531 WP_009910909.1 DUF1697 domain-containing protein -
K6971_RS09230 (K6971_09230) 1881784..1882041 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
K6971_RS09235 (K6971_09235) 1882043..1882303 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6971_RS09240 (K6971_09240) 1882379..1882834 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
K6971_RS09245 (K6971_09245) 1882841..1883170 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6971_RS09250 (K6971_09250) 1883160..1883447 - 288 WP_012028535.1 hypothetical protein -
K6971_RS09255 (K6971_09255) 1883545..1883913 - 369 WP_012775453.1 hypothetical protein -
K6971_RS09260 (K6971_09260) 1883906..1884475 - 570 WP_012775366.1 ribonuclease M5 -
K6971_RS09265 (K6971_09265) 1884459..1885241 - 783 WP_012028536.1 TatD family hydrolase -
K6971_RS09270 (K6971_09270) 1885348..1885485 - 138 WP_002939016.1 50S ribosomal protein L34 -
K6971_RS09275 (K6971_09275) 1885653..1886648 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1842014..1885241 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T214291 WP_012775363.1 NZ_CP082200:c1882041-1881784 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T214291 NZ_CP110018:3374453-3374917 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT214291 WP_002939010.1 NZ_CP082200:c1882303-1882043 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT214291 NZ_CP110018:3374118-3374453 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References