Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1889050..1889656 Replicon chromosome
Accession NZ_CP091422
Organism Streptococcus suis strain LSM157

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag L3X06_RS09275 Protein ID WP_012775364.1
Coordinates 1889050..1889379 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag L3X06_RS09280 Protein ID WP_012028535.1
Coordinates 1889369..1889656 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3X06_RS09245 (L3X06_09245) 1884462..1886192 - 1731 WP_012775361.1 membrane protein -
L3X06_RS09250 (L3X06_09250) 1886557..1887429 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
L3X06_RS09255 (L3X06_09255) 1887449..1887979 - 531 WP_009910909.1 DUF1697 domain-containing protein -
L3X06_RS09260 (L3X06_09260) 1887993..1888250 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
L3X06_RS09265 (L3X06_09265) 1888252..1888512 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
L3X06_RS09270 (L3X06_09270) 1888588..1889043 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
L3X06_RS09275 (L3X06_09275) 1889050..1889379 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L3X06_RS09280 (L3X06_09280) 1889369..1889656 - 288 WP_012028535.1 hypothetical protein Antitoxin
L3X06_RS09285 (L3X06_09285) 1889754..1890122 - 369 WP_012775453.1 hypothetical protein -
L3X06_RS09290 (L3X06_09290) 1890115..1890684 - 570 WP_012775366.1 ribonuclease M5 -
L3X06_RS09295 (L3X06_09295) 1890668..1891450 - 783 WP_012028536.1 TatD family hydrolase -
L3X06_RS09300 (L3X06_09300) 1891557..1891694 - 138 WP_002939016.1 50S ribosomal protein L34 -
L3X06_RS09305 (L3X06_09305) 1891862..1892857 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -
L3X06_RS09310 (L3X06_09310) 1892877..1893689 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
L3X06_RS09315 (L3X06_09315) 1893673..1894032 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1848223..1891450 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T233292 WP_012775364.1 NZ_CP091422:c1889379-1889050 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T233292 NZ_HG326223:c4449668-4449288 [Serratia marcescens subsp. marcescens Db11]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAGGGACGTTCT
GGTCGAGTATCACATCAATCCGGCCATCAGCGCCATCACCTGGATGGAAGTGATGGTAGGTGCTAAAAAACAGGGTCCGG
CACTGGAGCTGAAAACACGTCAGTTTTTAGGGCAATTTCTGCTGCTGCCTATTACCGATGAAGTCGCTGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAACTGCCAGACGCCATTATCTGGGCCACAGCGCAGGTGGGATTCCGGATGCTCAT
CTCCCGCAACCCCAAAGATTTCGGCACTGACAATGGCGTGTTGATGCCTTATCGGCTGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT233292 WP_012028535.1 NZ_CP091422:c1889656-1889369 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT233292 NZ_HG326223:c4449889-4449668 [Serratia marcescens subsp. marcescens Db11]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGATAATCTGAAAAATATCCGCCACGTTCCGCG
GGCCGAGATCATTCGTCAAGCAGTCTCCCGCTATCTGACGGAGAACCACGTGGAAGATCCCAGCAACGCTTTCGGGCTCT
GGTCCGGGGCGATGGGAGATGGCGTGGAGTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References