262476

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1915143..1915662 Replicon chromosome
Accession NZ_CP109942
Organism Streptococcus suis strain ID35541

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag OHM48_RS09420 Protein ID WP_012775363.1
Coordinates 1915143..1915400 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag OHM48_RS09425 Protein ID WP_002939010.1
Coordinates 1915402..1915662 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM48_RS09405 (OHM48_09405) 1911612..1913342 - 1731 WP_012775361.1 membrane protein -
OHM48_RS09410 (OHM48_09410) 1913707..1914579 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
OHM48_RS09415 (OHM48_09415) 1914599..1915129 - 531 WP_009910909.1 DUF1697 domain-containing protein -
OHM48_RS09420 (OHM48_09420) 1915143..1915400 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
OHM48_RS09425 (OHM48_09425) 1915402..1915662 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OHM48_RS09430 (OHM48_09430) 1915738..1916193 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
OHM48_RS09435 (OHM48_09435) 1916200..1916529 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
OHM48_RS09440 (OHM48_09440) 1916519..1916806 - 288 WP_012028535.1 hypothetical protein -
OHM48_RS09445 (OHM48_09445) 1916904..1917272 - 369 WP_012775453.1 hypothetical protein -
OHM48_RS09450 (OHM48_09450) 1917265..1917834 - 570 WP_012775700.1 ribonuclease M5 -
OHM48_RS09455 (OHM48_09455) 1917818..1918600 - 783 WP_012028536.1 TatD family hydrolase -
OHM48_RS09460 (OHM48_09460) 1918707..1918844 - 138 WP_002939016.1 50S ribosomal protein L34 -
OHM48_RS09465 (OHM48_09465) 1919012..1920007 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1875488..1918600 43112


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T262476 WP_012775363.1 NZ_CP109942:c1915400-1915143 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT262476 WP_002939010.1 NZ_CP109942:c1915662-1915402 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References