Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1880961..1881567 Replicon chromosome
Accession NZ_CP082199
Organism Streptococcus suis strain Transconjugant cFJSM5

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag K6970_RS09220 Protein ID WP_012775364.1
Coordinates 1880961..1881290 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag K6970_RS09225 Protein ID WP_012028535.1
Coordinates 1881280..1881567 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6970_RS09190 (K6970_09190) 1876373..1878103 - 1731 WP_012775361.1 membrane protein -
K6970_RS09195 (K6970_09195) 1878468..1879340 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
K6970_RS09200 (K6970_09200) 1879360..1879890 - 531 WP_009910909.1 DUF1697 domain-containing protein -
K6970_RS09205 (K6970_09205) 1879904..1880161 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
K6970_RS09210 (K6970_09210) 1880163..1880423 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6970_RS09215 (K6970_09215) 1880499..1880954 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
K6970_RS09220 (K6970_09220) 1880961..1881290 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6970_RS09225 (K6970_09225) 1881280..1881567 - 288 WP_012028535.1 hypothetical protein Antitoxin
K6970_RS09230 (K6970_09230) 1881665..1882033 - 369 WP_012775453.1 hypothetical protein -
K6970_RS09235 (K6970_09235) 1882026..1882595 - 570 WP_012775366.1 ribonuclease M5 -
K6970_RS09240 (K6970_09240) 1882579..1883361 - 783 WP_012028536.1 TatD family hydrolase -
K6970_RS09245 (K6970_09245) 1883468..1883605 - 138 WP_002939016.1 50S ribosomal protein L34 -
K6970_RS09250 (K6970_09250) 1883773..1884768 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -
K6970_RS09255 (K6970_09255) 1884788..1885600 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
K6970_RS09260 (K6970_09260) 1885584..1885943 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1840134..1883361 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T214287 WP_012775364.1 NZ_CP082199:c1881290-1880961 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T214287 NZ_CP110018:c3003004-3002669 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT214287 WP_012028535.1 NZ_CP082199:c1881567-1881280 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT214287 NZ_CP110018:c3003252-3003004 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References