24001

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1826354..1826873 Replicon chromosome
Accession NC_012925
Organism Streptococcus suis P1/7

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K1SXY6
Locus tag SSU_RS09045 Protein ID WP_012775363.1
Coordinates 1826354..1826611 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag SSU_RS09050 Protein ID WP_002939010.1
Coordinates 1826613..1826873 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSU_RS09030 1822823..1824553 - 1731 WP_012775361.1 membrane protein -
SSU_RS09035 1824918..1825826 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
SSU_RS09040 1825810..1826340 - 531 WP_009910909.1 DUF1697 domain-containing protein -
SSU_RS09045 1826354..1826611 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin Toxin
SSU_RS09050 1826613..1826873 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SSU_RS09055 1826949..1827404 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
SSU_RS09060 1827411..1827740 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
SSU_RS09065 1827730..1828017 - 288 WP_012028535.1 hypothetical protein -
SSU_RS09070 1828115..1828483 - 369 WP_012775453.1 hypothetical protein -
SSU_RS09075 1828476..1829045 - 570 WP_012775366.1 ribonuclease M5 -
SSU_RS09080 1829029..1829811 - 783 WP_012028536.1 TatD family hydrolase -
SSU_RS09085 1829918..1830055 - 138 WP_002939016.1 50S ribosomal protein L34 -
SSU_RS09090 1830223..1831218 - 996 WP_012775367.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1786584..1829811 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.81 Da        Isoelectric Point: 7.2737

>T24001 WP_012775363.1 NC_012925:c1826611-1826354 [Streptococcus suis P1/7]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T24001 NC_012925:c1826611-1826354 [Streptococcus suis P1/7]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCCAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT24001 WP_002939010.1 NC_012925:c1826873-1826613 [Streptococcus suis P1/7]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT24001 NC_012925:c1826873-1826613 [Streptococcus suis P1/7]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1SXY6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References