288906

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1862809..1863415 Replicon chromosome
Accession NZ_LR738721
Organism Streptococcus suis isolate S10

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag GPW51_RS09350 Protein ID WP_012775364.1
Coordinates 1862809..1863138 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag GPW51_RS09355 Protein ID WP_012028535.1
Coordinates 1863128..1863415 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW51_RS09320 1858221..1859951 - 1731 WP_012775361.1 membrane protein -
GPW51_RS09325 1860316..1861224 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
GPW51_RS09330 1861208..1861738 - 531 WP_009910909.1 DUF1697 domain-containing protein -
GPW51_RS09335 1861752..1862009 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
GPW51_RS09340 1862011..1862271 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPW51_RS09345 1862347..1862802 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
GPW51_RS09350 1862809..1863138 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPW51_RS09355 1863128..1863415 - 288 WP_012028535.1 hypothetical protein Antitoxin
GPW51_RS09360 1863513..1863881 - 369 WP_012775453.1 hypothetical protein -
GPW51_RS09365 1863874..1864443 - 570 WP_012775366.1 ribonuclease M5 -
GPW51_RS09370 1864427..1865209 - 783 WP_012028536.1 TatD family hydrolase -
GPW51_RS09375 1865316..1865453 - 138 WP_002939016.1 50S ribosomal protein L34 -
GPW51_RS09380 1865621..1866616 - 996 WP_012775367.1 protein jag -
GPW51_RS09385 1866636..1867448 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
GPW51_RS09390 1867432..1867791 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1821982..1865209 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T288906 WP_012775364.1 NZ_LR738721:c1863138-1862809 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT288906 WP_012028535.1 NZ_LR738721:c1863415-1863128 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References