Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-RelB |
Location | 1892850..1893369 | Replicon | chromosome |
Accession | NZ_CP030017 | ||
Organism | Streptococcus suis strain ISU1606 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | A0A2K1SXY6 |
Locus tag | DK235_RS09255 | Protein ID | WP_012775363.1 |
Coordinates | 1892850..1893107 (-) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A0K2E7Z9 |
Locus tag | DK235_RS09260 | Protein ID | WP_002939010.1 |
Coordinates | 1893109..1893369 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DK235_RS09240 | 1889319..1891049 | - | 1731 | WP_012775361.1 | membrane protein | - |
DK235_RS09245 | 1891414..1892322 | - | 909 | WP_012027884.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
DK235_RS09250 | 1892306..1892836 | - | 531 | WP_009910909.1 | DUF1697 domain-containing protein | - |
DK235_RS09255 | 1892850..1893107 | - | 258 | WP_012775363.1 | Txe/YoeB family addiction module toxin | Toxin |
DK235_RS09260 | 1893109..1893369 | - | 261 | WP_002939010.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
DK235_RS09265 | 1893445..1893900 | - | 456 | WP_012028534.1 | 8-oxo-dGTP diphosphatase | - |
DK235_RS09270 | 1893907..1894236 | - | 330 | WP_012775364.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
DK235_RS09275 | 1894226..1894513 | - | 288 | WP_012028535.1 | hypothetical protein | - |
DK235_RS09280 | 1894611..1894979 | - | 369 | WP_012775453.1 | hypothetical protein | - |
DK235_RS09285 | 1894972..1895541 | - | 570 | WP_012775366.1 | ribonuclease M5 | - |
DK235_RS09290 | 1895525..1896307 | - | 783 | WP_012028536.1 | TatD family hydrolase | - |
DK235_RS09295 | 1896414..1896551 | - | 138 | WP_002939016.1 | 50S ribosomal protein L34 | - |
DK235_RS09300 | 1896719..1897714 | - | 996 | WP_012775367.1 | protein jag | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 1853080..1896307 | 43227 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10346.81 Da Isoelectric Point: 7.2737
>T106862 WP_012775363.1 NZ_CP030017:c1893107-1892850 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIQDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR
Download Length: 258 bp
>T106862 NZ_CP030017:c1893107-1892850 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCCAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCCAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9980.36 Da Isoelectric Point: 5.7134
>AT106862 WP_002939010.1 NZ_CP030017:c1893369-1893109 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD
Download Length: 261 bp
>AT106862 NZ_CP030017:c1893369-1893109 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2K1SXY6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0K2E7Z9 |