27112

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1860510..1861116 Replicon chromosome
Accession NC_017617
Organism Streptococcus suis GZ1

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag SSGZ1_RS09185 Protein ID WP_012775364.1
Coordinates 1860510..1860839 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag SSGZ1_RS09190 Protein ID WP_012028535.1
Coordinates 1860829..1861116 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSGZ1_RS09155 1855922..1857653 - 1732 Protein_1750 hypothetical protein -
SSGZ1_RS09160 1858018..1858926 - 909 WP_012027884.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
SSGZ1_RS09165 1858910..1859380 - 471 WP_014636158.1 DUF1697 domain-containing protein -
SSGZ1_RS09170 1859453..1859704 - 252 WP_041179125.1 Txe/YoeB family addiction module toxin -
SSGZ1_RS09175 1859713..1859972 - 260 Protein_1754 type II toxin-antitoxin system Phd/YefM family antitoxin -
SSGZ1_RS09180 1860048..1860503 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
SSGZ1_RS09185 1860510..1860839 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSGZ1_RS09190 1860829..1861116 - 288 WP_012028535.1 hypothetical protein Antitoxin
SSGZ1_RS09195 1861214..1861582 - 369 WP_012775453.1 hypothetical protein -
SSGZ1_RS09200 1861575..1862144 - 570 WP_012775366.1 ribonuclease M5 -
SSGZ1_RS09205 1862128..1862910 - 783 WP_012028536.1 TatD family hydrolase -
SSGZ1_RS09210 1863017..1863154 - 138 WP_002939016.1 50S ribosomal protein L34 -
SSGZ1_RS09215 1863322..1864317 - 996 WP_012775367.1 protein jag -
SSGZ1_RS09220 1864337..1865149 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
SSGZ1_RS09225 1865133..1865492 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1819684..1862910 43226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T27112 WP_012775364.1 NC_017617:c1860839-1860510 [Streptococcus suis GZ1]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T27112 NC_017617:c1860839-1860510 [Streptococcus suis GZ1]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT27112 WP_012028535.1 NC_017617:c1861116-1860829 [Streptococcus suis GZ1]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT27112 NC_017617:c1861116-1860829 [Streptococcus suis GZ1]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References