214282

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1885401..1886007 Replicon chromosome
Accession NZ_CP082198
Organism Streptococcus suis strain Transconjugant cNJ3

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag K6968_RS09260 Protein ID WP_012775364.1
Coordinates 1885401..1885730 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag K6968_RS09265 Protein ID WP_012028535.1
Coordinates 1885720..1886007 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6968_RS09230 (K6968_09230) 1880813..1882543 - 1731 WP_012775361.1 membrane protein -
K6968_RS09235 (K6968_09235) 1882908..1883780 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
K6968_RS09240 (K6968_09240) 1883800..1884330 - 531 WP_009910909.1 DUF1697 domain-containing protein -
K6968_RS09245 (K6968_09245) 1884344..1884601 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
K6968_RS09250 (K6968_09250) 1884603..1884863 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6968_RS09255 (K6968_09255) 1884939..1885394 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
K6968_RS09260 (K6968_09260) 1885401..1885730 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6968_RS09265 (K6968_09265) 1885720..1886007 - 288 WP_012028535.1 hypothetical protein Antitoxin
K6968_RS09270 (K6968_09270) 1886105..1886473 - 369 WP_012775453.1 hypothetical protein -
K6968_RS09275 (K6968_09275) 1886466..1887035 - 570 WP_012775366.1 ribonuclease M5 -
K6968_RS09280 (K6968_09280) 1887019..1887801 - 783 WP_012028536.1 TatD family hydrolase -
K6968_RS09285 (K6968_09285) 1887908..1888045 - 138 WP_002939016.1 50S ribosomal protein L34 -
K6968_RS09290 (K6968_09290) 1888213..1889208 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -
K6968_RS09295 (K6968_09295) 1889228..1890040 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
K6968_RS09300 (K6968_09300) 1890024..1890383 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1844574..1887801 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T214282 WP_012775364.1 NZ_CP082198:c1885730-1885401 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T214282 NZ_CP110018:2166601-2166975 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT214282 WP_012028535.1 NZ_CP082198:c1886007-1885720 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT214282 NZ_CP110018:2166144-2166512 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References