Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RelB(antitoxin) |
Location | 1976269..1976875 | Replicon | chromosome |
Accession | NZ_CP091423 | ||
Organism | Streptococcus suis strain LSM29 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A0Z8ZB64 |
Locus tag | L3X15_RS09690 | Protein ID | WP_012775364.1 |
Coordinates | 1976269..1976598 (-) | Length | 110 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | D5AKB4 |
Locus tag | L3X15_RS09695 | Protein ID | WP_012028535.1 |
Coordinates | 1976588..1976875 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L3X15_RS09660 (L3X15_09660) | 1971681..1973411 | - | 1731 | WP_012775361.1 | membrane protein | - |
L3X15_RS09665 (L3X15_09665) | 1973776..1974648 | - | 873 | WP_012775362.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
L3X15_RS09670 (L3X15_09670) | 1974668..1975198 | - | 531 | WP_009910909.1 | DUF1697 domain-containing protein | - |
L3X15_RS09675 (L3X15_09675) | 1975212..1975469 | - | 258 | WP_012775363.1 | Txe/YoeB family addiction module toxin | - |
L3X15_RS09680 (L3X15_09680) | 1975471..1975731 | - | 261 | WP_002939010.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
L3X15_RS09685 (L3X15_09685) | 1975807..1976262 | - | 456 | WP_012028534.1 | 8-oxo-dGTP diphosphatase | - |
L3X15_RS09690 (L3X15_09690) | 1976269..1976598 | - | 330 | WP_012775364.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
L3X15_RS09695 (L3X15_09695) | 1976588..1976875 | - | 288 | WP_012028535.1 | hypothetical protein | Antitoxin |
L3X15_RS09700 (L3X15_09700) | 1976973..1977341 | - | 369 | WP_012775453.1 | hypothetical protein | - |
L3X15_RS09705 (L3X15_09705) | 1977334..1977903 | - | 570 | WP_012775366.1 | ribonuclease M5 | - |
L3X15_RS09710 (L3X15_09710) | 1977887..1978669 | - | 783 | WP_012028536.1 | TatD family hydrolase | - |
L3X15_RS09715 (L3X15_09715) | 1978776..1978913 | - | 138 | WP_002939016.1 | 50S ribosomal protein L34 | - |
L3X15_RS09720 (L3X15_09720) | 1979081..1980076 | - | 996 | WP_012775367.1 | RNA-binding cell elongation regulator Jag/EloR | - |
L3X15_RS09725 (L3X15_09725) | 1980096..1980908 | - | 813 | WP_012027897.1 | YidC/Oxa1 family membrane protein insertase | - |
L3X15_RS09730 (L3X15_09730) | 1980892..1981251 | - | 360 | WP_004194560.1 | ribonuclease P protein component | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 1935442..1978669 | 43227 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12562.52 Da Isoelectric Point: 7.1991
>T233297 WP_012775364.1 NZ_CP091423:c1976598-1976269 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK
Download Length: 330 bp
>T233297 NZ_HG738867:c1156443-1156336 [Escherichia coli str. K-12 substr. MC4100]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10892.43 Da Isoelectric Point: 4.3464
>AT233297 WP_012028535.1 NZ_CP091423:c1976875-1976588 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI
Download Length: 288 bp
>AT233297 NZ_HG738867:1156491-1156557 [Escherichia coli str. K-12 substr. MC4100]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z8ZB64 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z9A6F4 |