Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1976269..1976875 Replicon chromosome
Accession NZ_CP091423
Organism Streptococcus suis strain LSM29

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag L3X15_RS09690 Protein ID WP_012775364.1
Coordinates 1976269..1976598 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag L3X15_RS09695 Protein ID WP_012028535.1
Coordinates 1976588..1976875 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3X15_RS09660 (L3X15_09660) 1971681..1973411 - 1731 WP_012775361.1 membrane protein -
L3X15_RS09665 (L3X15_09665) 1973776..1974648 - 873 WP_012775362.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
L3X15_RS09670 (L3X15_09670) 1974668..1975198 - 531 WP_009910909.1 DUF1697 domain-containing protein -
L3X15_RS09675 (L3X15_09675) 1975212..1975469 - 258 WP_012775363.1 Txe/YoeB family addiction module toxin -
L3X15_RS09680 (L3X15_09680) 1975471..1975731 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
L3X15_RS09685 (L3X15_09685) 1975807..1976262 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
L3X15_RS09690 (L3X15_09690) 1976269..1976598 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L3X15_RS09695 (L3X15_09695) 1976588..1976875 - 288 WP_012028535.1 hypothetical protein Antitoxin
L3X15_RS09700 (L3X15_09700) 1976973..1977341 - 369 WP_012775453.1 hypothetical protein -
L3X15_RS09705 (L3X15_09705) 1977334..1977903 - 570 WP_012775366.1 ribonuclease M5 -
L3X15_RS09710 (L3X15_09710) 1977887..1978669 - 783 WP_012028536.1 TatD family hydrolase -
L3X15_RS09715 (L3X15_09715) 1978776..1978913 - 138 WP_002939016.1 50S ribosomal protein L34 -
L3X15_RS09720 (L3X15_09720) 1979081..1980076 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -
L3X15_RS09725 (L3X15_09725) 1980096..1980908 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
L3X15_RS09730 (L3X15_09730) 1980892..1981251 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1935442..1978669 43227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T233297 WP_012775364.1 NZ_CP091423:c1976598-1976269 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T233297 NZ_HG738867:c1156443-1156336 [Escherichia coli str. K-12 substr. MC4100]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT233297 WP_012028535.1 NZ_CP091423:c1976875-1976588 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT233297 NZ_HG738867:1156491-1156557 [Escherichia coli str. K-12 substr. MC4100]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References